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Life Science
Every biological organism has an individual set of genes, a typical set of proteins and a dynamic set of metabolites. Compared to the genome, the individual set of proteins and metabolites is dynamic and dependent on the respective constitution of the organism, its age or current burden.
Proteomics studies the structures and general functions of proteins and endeavours to deduce generally applicable scientific data or phenotyping, for example of diseases.
The examination of metabolites provides a snapshot of the current state of the organism; this is called metabolic profiling. This method is used in particular to examine substances for toxicity prior to clinical studies, to identify of genetically modified organisms and in nutrition science.
Bruker supplies unique analytical methods and superior technological systems in the fast-growing scientific fields of genomics, proteomics and metabonomics.
Molecular Magnetic Resonance Imaging (MRI)
Molecular MR imaging is aimed at detecting the origins of disease related pathways and targets by combining the use of molecular biomarkers.
Visualization of the spatial distribution of proteins, drug candidate compounds and biomarkers is a promising tool in the exciting fields of biomarker evaluation and drug development. MALDI-TOF mass spectrometry, with our unique ImagePrep sample preparation tool provides a fast and reliable screening tool for direct analysis from tissue.
The rapid, unambiguous and comprehensive identification of metabolic changes is an important task in drug discovery. MS techniques and corresponding Bioinformatics are particularly useful tools to resolve molecular formulae and structural information of the analytes.
Screening for Inborn Errors of Metabolism (NMR)
NMR can help to diagnose metabolic disorders in newborns and children.
Distance Determination in Proteins (EPR)
Precise measurement of electron-electron interspin distances in the range 20-80 Å is becoming more and more important, e.g. in cardiology research.