MALDI Imaging allows direct label-free measurement of proteins, peptides, lipids, drugs, and metabolites from tissue. The distribution of the detected compounds can be visualized as images which can be integrated with other imaging modalities to study the molecular signatures of tissue compartments.
Defining a new type of molecular histology
The histological context of a molecular measurement is crucial for the correct interpretation of molecular imaging data. Conventional histological staining can be performed on the same tissue section. Bruker’s unique software can overlay a high resolution virtual microscopy slide with the molecular image. This effectively turns MALDI Imaging into standard histology with an added molecular dimension.
For more information, see the video demonstrations of a rat testis and a pancreas dataset.
Location and quantitation of drug and metabolites
MALDI Imaging allows the measurement of drug distribution in tissue. Furthermore it allows the molecular differentiation of the parent drug and metabolites. The combination of MALDI Imaging with the histology gives additional insight and allows to bridge biology and chemistry in drug development.