Imaging VIP Day

Poster Hall Pharma/Biopharma

The ever increasing need to accelerate time to market for new drugs places a burden on analytical labs in terms of sample volume and confidence in data required for decision making. Innovations in trapped ion mobility mass spectrometry and software give BioPharma scientist new tools to characterize biologic drugs with more speed and keep up with the pace of development. Mass spectrometry imaging is becoming an essential tool to understand diseases and determine drugs PK and metabolism which are essential to address the right tissue and evaluate toxicity early.

ASMS 2020

Poster 2020: Identification and differentiation of disulfide bonded isomers of the µ-conotoxin PIIIA by trapped ion mobility spectrometry

Poster 2020: Integrated characterization and screening workflows to simplify the design of MAM methods

Poster 2020: Use of PASEF for Accelerated Protein Sequence Confirmation and de novo Sequencing with High Data Quality

Poster 2020: Sensitive drug distribution measurements of an ADC with non-denaturing capillary SEC

Poster 2020: Intact Protein Multi-Attribute Method (MAM) that Includes the Identification and Quantification of Protein Clipping Events

Poster 2020: Enhanced detection of host cell proteins enabled by use of collisional cross section values

Poster 2020: Peptide structure confirmation with isomer distinction based on molecular weight and collision cross section obtained with trapped ion mobility separation

Poster 2020: Characterization of API impurities and degradation products by ion mobility LC-timsTOF Pro with parallel accumulation serial fragmentation (PASEF)

Poster 2020: Novel High-Throughput MALDI-TOF MS Workflow for Screening of Different Analytes at Each Position on a Plate

Poster 2020: Multiplexed Analytical Platform using Affinity Capture and MALDI MS Enables Novel Assay Development for Screening Biomarkers of Neurological Diseases

Poster 2020: Trapped Ion Mobility Spectrometry (TIMS) enables differentiation of isobaric N-glycan isomers (by specific collisional cross sections)

Poster 2020: Reproducibility of native SEC LC-MS intact mAb characterisation measurements

Poster 2020: Assaying Protein / Ligand Binding with High-Resolution Native Mass Spectrometry

ASMS 2019

Poster 2019: Simultaneous Profile and Determination of Statin Composition in Various Media and Biological Matrices by Accurate Mass and High Resolution LC-QTOF-MS

Poster 2019: CHO Cell Culture Media Profiling and Unknown Identification by Liquid Chromatography and Accurate Mass High Resolution Mass Spectrometry

Poster 2019: Structural study of a PEGylated therapeutic protein by MALDI-ISD and ESI-QTOF

Poster 2019: Streamlining mAb characterization with a PASEF based disulfide analysis workflow

Poster 2019: Separation of Asp/IsoAsp Isobaric Peptides using Trapped Ion Mobility Spectrometry (TIMS)

Poster 2019: The benefit of peptide CCS value prediction and experimental determination

Poster 2019: A software platform for peptide synthesis quality control by both LC-free MALDI-TOF and LC-ESI-QTOF molecular weight determination

Poster 2019: A software platform for the quality control of synthetic oligonucleotides

Poster 2019: Optimized data analysis pipeline for MALDI imaging based tumor typing from FFPE tissue samples evaluated on six benchmark classification tasks

Poster 2019: Predicting Lymph Node Metastasis in Endometrial Cancer by multi-modal mass spectrometry imaging

Poster 2019: Mass Spectrometric In-Depth Proteome Analysis of the Kidneys from Rat Model of Diabetic Nephropathy

Poster 2019: Metabolomics Characterization of Cell Culture Media by Ultrahigh Resolution LC-QTOF-MS Analysis

Poster 2019: Analysis of Histones from HEK293 Cells using a QTOF with Trapped Ion Mobility and PASEF Workflows

Poster 2019: Identification and Quantitation of Phosphopeptide Positional Isomers using Trapped Ion Mobility Spectrometry and PASEF

Bottom-up protein characterization

Poster 2018: Routine Analysis of Host Cell Proteins in Antibody Preparations using PASEF

Poster 2018: Application of PASEF MS/MS scans to monoclonal antibody peptide mapping

Poster 2018: A unified workflow for automatic mapping of disulfide bonds in protein therapeutics based on high resolution LC-QTOF

Intact protein characterization

Poster 2018: Characterization of a Fusion Protein Dimer by a UHR ESI - QTOF Mass Spectrometer

Mass Spec Imaging 

Poster 2018: MALDI Imaging Mass Spectrometry for the study of cardiovascular pathology

Poster 2018: Distinct deposition of amyloid-bspecies in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry

Poster 2018: Hepatic Lipid Analysis in an Experimental Model of Chronic Alcohol Exposure using of MALDI-TOF and MALDI-FT-ICR Mass Spectrometry

MALDI based protein characterization

Poster 2018: Rapid Identity Assays for mAb Development, Production Control and Release