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The Fundamentals of AFM Probe Selection, 2020 Edition

Watch this webinar to learn the fundamentals of choosing the AFM probe that is optimal for your latest application, and learn about our latest probes.
This webinar took place on August 12th 2020

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The webinar covers the fundamentals of the AFM probe design, and how the probe design is fundamental to selecting the proper probe for different applications. The two broad applications covered are biological applications and materials science applications. In each of these two applications, the latest developed probes are highlighted.

For Bio applications, high resolution AFM probes for visualizing single molecules are discussed, as well as cell imaging, and mechanical measurements.

For material science, we start with topography imaging before moving on to nanomechanics and nanoelectrical characterization. The webinar highlights the updated probes website.

Detailed Abstract

Atomic force microscopy is a high-resolution form of scanning probe microscope, which involves the scanning of a surface with a mechanical probe. The probe is an important component of a successful AFM experiment. There are multiple applications of AFM, so it is important to select the right probe for the sample. The materials and design of the AFM probe are in important part on what the probe can be used for. The fabrication process of the probes at Bruker can be highly specialized at different levels. The cantilever design is essential to how the tip will interact with the sample with regards to the stiffness and the frequency. The design of the tip will be discussed on when a sharp tip is appropriate, and when a broader tip may be appropriate, with notable examples for each. Biological applications will be discussed regarding hydrogels, soft samples, living cells and tissues. Biological molecules will also be discussed with regards to high resolution imaging and single molecule studies. Large radius probes for biological applications will be highlighted. Materials applications will be highlighted, with discussions on how to select for nanomechanical and nanoelectrical applications of the AFM probe. NanoDMA pre-calbrated probes will be discussed as the latest development for materials research.


Mickael Febvre, Ph.D.
Mickael Febvre, Ph.D.
EMEA Applications Director, Bruker
Alexander Dulebo, Ph.D.
Alexander Dulebo, Ph.D.
Bio Sales Application Engineer, Bruker
Alexander Portillo, Ph.D., M.S.
Alexander Portillo, Ph.D., M.S.
Sales and Marketing, Sr. Representative, Bruker