The high demand in clinical research and forensic toxicology for comprehensive, specific, and transferable techniques has led to new developments in the field of Liquid Chromatography-tandem Mass Spectrometry (LC-MS). LC-MSn, combined with library searching, is one of the most promising screening solutions for modern toxicology research.
The Toxtyper 2.0 holds a high quality spectral library of more than 980 compounds of toxicology research interest with ˜ 3,000 spectra of MS, MS² and MS³ experiments and a smaller targeted library for Drugs of Abuse screening research. The library search module, as part of Brukers' new Toxtyper 2.0 software package, allows for unambiguous and fast (11-minute duty cycle) drug identification. In addition, the Toxtyper supports the Maurer/Wissenbach/Weber LC-MSn library* containing > 4500 drugs, metabolites, and artifacts.