The Frame Inject feature in the Sierra SPR-24 Pro system allows the investigation of condition dependent binding / mode of action studies. The feature requires just a fraction of each buffer condition, that replaces the system buffer while usage. The pre-association, as well as the dissociation occurs under the conditions, that should be investigated. After dissociation end, frame solution buffer is replaced and system buffer is flowingthrough the microfluidic system again. Thus experimental time and reagent costs are kept low. The same buffer can be directed to all flow cells, or up to eight different buffers can be assayed simultaneously.

Frame Inject allows the investigation of up to eight buffer conditions in parallel.