From initial screening to detailed kinetic characterization and thermodynamics measurements, the Sierra SPR-32 system enables high-throughput surface plasmon resonance (SPR) analysis of molecular interactions. Equipped with 32 individually addressable detection spots, this highly sensitive real-time, label-free analytical system is uniquely configured to provide active and control binding data for small molecules, fragments, proteins, peptides, antibodies and nucleic acids.
Four independently addressable detection spots are configured in each of the eight channels of the Sierra SPR-32 system. The four-sensor per channel design provides maximum flexibility for control analysis, while maintaining throughput for even the most complex analyses. Samples can be simultaneously tested on up to three control surfaces as well as the active surface. In many SPR applications, early detection of nonspecific binding to control proteins is critical. In small molecule screening and characterization, binding to serum proteins such as HSA or AGP is an integral part of drug development. The additional in-channel control not only halves the number of assay cycles required but also improves data quality by eliminating potential variations between multiple sample preparations.
