The leading analytical tools in structural biology have traditionally been X-ray crystallography and liquid state NMR, but in recent years the role of solid state NMR has increased substantially through its ability to provide answers that neither liquids NMR nor X-ray can provide in a clear enough manner.
However, a serious problem that has limited the adoption of solid state NMR in structural biology has been the rather difficult setup of experiments, in both ensuring that they run efficiently, and also finally provide good data. Solid state NMR still requires trained spectroscopists in order to achieve great results, even in standard backbone assignment experiments, and even the most basic experiment can pose a challenge to hardware performance and instrument stability.
However, over the last decade the hardware has become increasingly stable and now delivers very high performance, achieving good reproducibility without the need for a trained rf-wizard to be present.
Over the same period, software development failed to keep pace with the advancements of hardware, but now a new dedicated software has closed that gap by providing an easy, interactive platform for conducting all basic solid state NMR experiments in structural biology.
Armed with only a basic knowledge of nuclear magnetic resonance basics, anyone can rely on the new software for easy set up of all backbone assignment and distance constraint experiments, making it ideal for the non-expert. And yet the expert also benefits, by an easy workflow that reduces the time to success by a factor of two, and reduces the probability of user error to virtually nothing.