A comprehensive view of brain inflammation during the pathogenesis of autoimmune encephalomyelitis (EAE) can be achieved with the aid of high resolution non-invasive imaging techniques. With the MRI CryoProbe, inflammatory infiltrates within various regions of the brain, can be studied in detail – even without the use of contrast agents – and show excellent correspondence with conventional histology. This opens up the real opportunity to follow neuroinflammatory processes even during the early stages of disease progression. High-resolution MRI does not only complement conventional histology but also enables longitudinal studies on the kinetics and dynamics of immune cell infiltration (2-4).
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3. Lepore S, Waiczies H, Hentschel J, Ji Y, Skodowski J, Pohlmann A, Millward JM, Paul F, Wuerfel J, Niendorf T, Waiczies S. Enlargement of cerebral ventricles as an early indicator of encephalomyelitis. PLoS One 2013;8(8):e72841.
4. Waiczies H, Millward JM, Lepore S, Infante-Duarte C, Pohlmann A, Niendorf T, Waiczies S. Identification of cellular infiltrates during early stages of brain inflammation with magnetic resonance microscopy. PLoS One 2012;7(3):e32796.