EPR in Pharma

Pharmaceutical Applications of EPR

Detecting and Evaluating Degradation

Therapeutic drugs require a well characterized shelf-life to ensure correct dosage and patient safety. Developing successful formulations depends on a thorough understanding of their chemical and physical stability and properties. Heat, light, oxygen, moisture, sterilization processes, impurities, and excipient interactions are some of the factors that can compromise product stability. Moreover, all these factors may cause degradation of the active pharmaceutical ingredients (APIs), excipients, or formulations resulting in loss of product potency or toxic by-product generation. Degradation processes quite often involve free radicals and transition metals that are responsible for the majority of the damage that occurs in drug products.

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