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NMR Clinical Solutions

B.I. Quant-PS

New plasma and serum quantification package , which detects and quantifies up to 40 different metabolites .

Highlights

The Bruker IVDr platform is optimized towards supporting the analysis of epidemiological studies with large scale, dedicated clinical and translational trials, and high throughput Biobank quality control. Based on nuclear magnetic resonance (NMR) spectroscopy, the standardized Bruker IVDr Methods module (B.I. Methods) guarantees high reproducibility and transferability under full automation at anytime and anywhere what is not achievable by any other analytical tool.

This standardized platform allows to combine different solutions. For plasma/serum, it means Bruker IVDr Lipoprotein Subclass Analysis (B.I.LISA™) and automated quantification of small molecule metabolites (B.I.QUANT-PS™) using the same experiment. B.I.QUANT-PS 2.0 offers the quantification  from 26 metabolites up to 41 metabolites.  

Eigenschaften

Features

  • Includes 41 metabolites (free metabolites, no protein denaturing done) with concentration ranges, occurring in most human plasma/serum samples
  • ƒƒIncludes matrix identity test, differentiation between EDTA plasma and heparin plasma or serum
  • In the analysis report, the metabolites are grouped according to their chemical class- Alcohols and derivatives- Amines and derivatives- Amino acids and derivatives- Carboxylic acids- Essential nutrient- Keto acids and derivatives- Sugars and derivatives- Sulfones- Technical additives
     
Interactive graphics of Alanine on a B.I.QUANT-PS 2.0 PDF report. It is an ideal situation, where the fit corresponds fully to the metabolite signal well above LOD, the raw concentration (r) is close to the result concentration and the correlation (ρ) is > 95% and the residue (Δ) is close to zero mmol/L.

Vorteile

Benefits

  • ƒEase of use, simple and rapid sample preparation
  • Fully automated quantification of 41 metabolites
  • Different analytes classes can be quantified simultaneously in a single run
  • Absolute concentration for each metabolite is given due to the calibration with one Quantification Reference sample (B.I.Methods™)
  • Validation of all LODs has been done following ISO 17025 guidelines for wet spiking
  • Raw concentration and additional ƒquantification result assessment information (correlation and residue) for each metabolite is given even below LOD
  • Interactive PDF report allowing visual fit ambiguity assessment
  • Rapid analysis: daily 120 samples can be prepared, measured and analyzed
  • Retrospective analysis possible if the sample was prepared and measured using B.I.Methods module
  • Works on plasma or serum sample
     
Extract of B.I.QUANT-PS 2.0 of a serum

Anwendungen

Spezifikationen

Specifications

  • Bruker IVDr platform or compatible AVANCE™ III HD or AVANCE NEO 600 MHz systems
  • Use of B.I.Methods module and SOPs for plasma/serum for sample preparation and measurement
  • Regular quality control of the absolute temperature, solvent suppression and quantification reference sample (preferably daily using automated quality control tool including in
    B.I.Methods)
  • Access to Bruker Data Analysis server for fully automated remote analysis (transfer of spectra after measurement to Bruker server via private ftp, back-transfer of result PDF report and XML file)

Webinare

Meinungen

Testimonials

Metabolic Profiling & Screening Using Advanced NMR Technologies at CIC bioGUNE
Setting up the Australian National Phenome Centre
NMR in Metabolomics - Interview with Prof. Claudio Luchinat
Opening of the IVDr lab in Luebeck, Germany
Professor Jeremy Nicholson - Murdoch University
Interview with Prof Matthias Nauck from University Greifswald, Gemany on IVDr by NMR

Support

Labscape

Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory