Versatile Quadruple Resonance CryoProbe for Structural Biology Applications

New, versatile proton-optimized quadruple resonance NMR ‘inverse’ probe


The new QCI CryoProbe™ - a proton-optimized quadruple resonance NMR ‘inverse’ probe - increases sensitivity by about 400% on 1H and 13C compared to a room temperature QXI probe. 

The versatile probe features four fully independent channels that enable simultaneous decoupling on multiple nuclei such as 13C, 31P and 15N. This cost-efficient adaptability eliminates the need for probe changes, making it ideally suited to the study of RNA or DNA, whilst also enabling research on proteins, small molecules and metabolomic samples, something which has made Bruker’s TCI CryoProbe™ a success.

Several recent discoveries in RNA research make this probe a very timely introduction to the field of cutting edge NMR research. The cryogenically cooled preamplifier for deuterium guarantees highest sensitivity for the lock channel, resulting in excellent stability of the spectrometer. This also permits the use of as little as a few percent of deuterated solvents.  In addition the QCI CryoProbe™ is equipped  with cold preamplifiers for 1H  and 13C. The probe is compatible with shaped tubes for optimum performance on lossy samples.