Biomolecular NMR Made Easy

Designed to simplify biomolecular NMR, BioTop automates tasks based on user experience level.

Options range from selection of experiments to processed spectra without any interaction to customization using home written pulse programs.

bioTop aims to make biomolecular NMR accessible to everyone. It automates daily tasks involved in the setup of protein, DNA or RNA experiments, eliminating common sources of errors. Users can switch to full TopSpin functionality at any time, providing a degree of automation that works best for you.


  • Easy to use interface
  • Automated optimizations and setup
  • Fully automated processing up to 3D spectra (including pseudo3D and NUS)
  • Automated analysis of relaxation experiments using the Dynamics Center
  • Customization by adding user defined experiments


bioTop is integral part of TopSpin installation, which may be downloaded here.

User interface

BioTop “knows” your experiments. Based on your selection of experiments, bioTop optimizes and maintains consistency for commonly used and shared parameters. It also offers an easy import of parameters optimized for your sample if already done, as well as parameter reporting in PDF format for your documentation.

Suppported operating systems

Automated processing of datasets is currently supported up to 3D spectra including non-uniform sampling and pseudo3D spectra. Recorded a relaxation experiment? Within a mouse click you will get the analysis using Protein Dynamics Center, so you can assess the data quality in no time.

A graphical user interface helps the experienced user to include his own pulse programs and/or parameter sets. The possibility to start from an existing experiment description makes this a very easy task. Happy with the experiments already included? You can still use the user-defined section to rename experiments or resort them into presets that suit your needs.

System requirements

Any liquid state high resolution spectrometer running TopSpin 3.5, equipped with a triple channel (H/C/N) probe.

bioTop is included in TopSpin 3.5 (pl6+).


Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory

Download LabScape Brochure