Si78 PET CT

High Performance Total Body PET and CT for mice & rats with fast scan times with unparalleled quality

Two best in class imaging technologies, combined in one instrument. This complete solution was designed with the researcher in mind to offer unlimited possibilities for in vivo preclinical imaging applications.

Bruker's Full Field of View Accuracy SiPM PET technology, are now combined with low dose - high throughput SkyScan micro-CT. Offering a unique instrument, with supreme PET/CT imaging performance, the PET/CT Si78.

The PET/CT Si78 features homogeneous, high-resolution, and quantitative PET/CT imaging with a large field of view of 80 x up to 200 mm.

The unique low dose X-ray technology, combined with ultra-fast full body 3D CT scanning, the familiar ParaVision 360 software and a high-precision motorized animal transport system, simplifies your workflow.

  • Total Body PET for mice and rats
  • Full Field-of-View PET quantitative accuracy
  • Low-dose, high-contrast fast CT scans for longitudinal PET/CT studies, and excellent performance in demanding bone, cardiac, and lung applications
  • ParaVision 360 preclinical imaging workflows using validated multi-modal in vivo protocols and scan programs
  • Interactive scan planning, introducing PET and CT preclinical imaging methods and interactive geometry editors
  • Accurate touch screen animal positioning
  • Double-sided and fully open access to the imaging gantry with a minimum distance to the PET FOV for kinetic tracer studies
  • Single click, auto connect animal cradles for mice and rats, including anesthesia supply, animal warming, respiration and ECG sensors and gas exhaust sensors

Animal Cradles

Bruker animal cradles are designed for easy workflows in the preclinical imaging lab.
Animal life support and PET tracer application equipment can be interfaced to the main instrument with a single clip on action, with dedicated ports for:

  • Anesthesia systems
  • Life monitoring systems
  • PET catheter feedthroughs
  • Cardiac or respiration gating

Prep Station

Single click benchtop prep station is available, facilitating preparation of the animal prior imaging.

Software

Fully integrated ParaVision 360. ParaVision 360 enters the world of seamless multimodal imaging. Modern imaging laboratories using PET, CT or MR instruments profit from the fully integrated common imaging platform.

Technical PET Features

  • Patented continuous LYSO crystals, unrestrained by discrete layers, and high-resolution depth-of-interaction technology enable precise 3D localization of events. This precise event localization results in  constant and high spatial resolution when moving out of the center of the PET Field-of-View.
  • Consistent and reproducible tracer quantification within the entire FOV, regardless of object size, position and activity is enabled by the homogeneous spatial resolution.
  • Ultra-fast reconstruction (under 1min) using GPU reconstruction and MLEM reconstruction.
  • Exceptional count rate performance combined with 12% sensitivity for dynamic and gated studies for high temporal resolution and superior image quality.

 

Full Field of View and Accuracy

Full field of view and accuracy offers real, homogeneous sub-millimetric volumetric PET resolution and quantification in all three axes, in the entire field of view. This is possible due continuous crystal detectors with SiPM technology and true depth of interaction 3D precision equivalent to 10+ layer pixelated crystal detectors.

graphic_1.jpg

Technical PET Features

  • Patented continuous LYSO crystals, unrestrained by discrete layers, and high-resolution depth-of-interaction technology enable precise 3D localization of events. This precise event localization results in  constant and high spatial resolution when moving out of the center of the PET Field-of-View.
  • Consistent and reproducible tracer quantification within the entire FOV, regardless of object size, position and activity is enabled by the homogeneous spatial resolution.
  • Ultra-fast reconstruction (under 1min) using GPU reconstruction and MLEM reconstruction.
  • Exceptional count rate performance combined with 12% sensitivity for dynamic and gated studies for high temporal resolution and superior image quality.

Full Field of View and Accuracy

Full field of view and accuracy offers real, homogeneous sub-millimetric volumetric PET resolution and quantification in all three axes, in the entire field of view. This is possible due continuous crystal detectors with SiPM technology and true depth of interaction 3D precision equivalent to 10+ layer pixelated crystal detectors.

Technical Micro-CT Features

  • Microfocus X-ray source with adjustable energy and automatic filter setting allows optimized scanning protocol with minimized applied doses.
  • Fast and sensitive flat-panel detector resolving dynamics of mouse heart and lungs activities.
  • Patented spatial beam shaper reduces the X- ray dose by 2-5 times without degradation of image quality.
  • Accelerated GPU reconstruction supports beam hardening correction, misalignment compensation, ring artifact removal and many other options.
  • On-screen dose meter indicates applied dose to the animal based on information from individual analysis of X-ray images.
graphic_2.JPG

Technical Micro-CT Features

  • Microfocus X-ray source with adjustable energy and automatic filter setting allows optimized scanning protocol with minimized applied doses.
  • Fast and sensitive flat-panel detector resolving dynamics of mouse heart and lungs activities.
  • Patented spatial beam shaper reduces the X- ray dose by 2-5 times without degradation of image quality.
  • Accelerated GPU reconstruction supports beam hardening correction, misalignment compensation, ring artifact removal and many other options.
  • On-screen dose meter indicates applied dose to the animal based on information from individual analysis of X-ray images.

Contrast Enhanced MicroCT for PET Reference

PET/CT Si78

Whole body PET tracer biodistribution studies aimed to determine exact organ specific uptake can benefit from contrast enhanced microCT. Data shows representative mouse after combined injection 4 MBq  18F-FDG and Exitron 12000.

Si78 Apps 01

Total Body PET Capabilities

PET/CT Si78

Total body PET represents a unique capability for studying the biodistribution and kinetics of candidate tracers. The example above shows the results of one single FDG PET/CT acquisition with the Si78 with a 20 min dynamic PET acquisition and a 10 second CT acquisition.

PET/CT in Rat Abdomen & Thorax

PET/CT Si78

Whole body rat PET allows for tracer distribution studies throughout the abdomen and thorax. Some studies have shown that respiratory gating improves detection of small lesions. Example shows a typical rat imaged by PET/CT following dosing with 18F-FDG. PET were completed with respiratory monitoring and data was reconstructed with 8 gates. CT was reconstructed using image derived gating.

Range of CT only Applications

Si78 Apps 7a

PET/CT Si78

Mice Pulmonary: Oncology, Fibrosis, Emphysema

Si78 Apps 7b

Mice Pulmonary:

Oncology, Fibrosis, Emphysema

Si78 Apps 7c

Rabbits

Skull Ex-vivo:
Bone Density, Orthopedics, Metabolism

Na18F PET in Mice: A Spatial Resolution Case Study

PET/CT Si78

Na18F PET is a common clinical procedure to investigate bone metastasis. When used in mice, Na18F is often a challenge for spatial resolution, thin structures like ribs will typically be the hardest to resolve. The PET/CT Si78, featuring the latest SiPM detector technology, enables Full Field of View Accuracy which essentially means high resolution throughout the entire FoV with day-to-day reconstruction settings.

Neuroimaging in Rats

PET/CT Si78

18FDG PET/CT of healthy rat with metabolic activity of cerebral cortex, Harderian glands, and jaw muscles clearly resolved. MicroCT (50 µm) well defined skull, sinuses, and jaw structures.

Si78 Apps 04aSi78 Apps 04b

Cardiovascular Imaging

PET/CT Si78

Normal mouse 4 slice coronal plane PET/CT 18FDG heart right ventricle clearly resolved MicroCT (200 µm) with lung and heart shadow

Si78 Apps 6

LabScape

Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory

Download LabScape Brochure

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