Preclinical In Vivo Imaging

Contrast agent research

Use of barium sulfate contrast agent to image the GI tract with computed tomography

Angiography

Visualization of the vascular structure in the mouse brain

Bone research

In vivo scan of mouse hindlimb (knee) with 9 µm pixel size

Agriculture

Pseudocolored X-Ray Screening of Seeds for Viability

Cardiology

Transverse slice of a FDG PET CT overlay of the mouse heart. Image courtesy of Dr. W. Matthew Leevy, NDIIF, University of Notre Dame, Indiana, US

Cardiovascular

Full body in vivo scan of a mouse using contrast agent

Diet Control

PET/MR imaging of flank tumor in mouse: Correlation observed between metabolic tumor hetero geneity in PET and Anatomical heterogeneity inMRI during sequential acquisition. Courtesy of U. Mahmood, P Heidari and P . Habibollahi, MGH, Boston, US

Brain connectivity

Axial map of the major principle diffusion direction of a mouse brain enabling to investigate brain connectivity. Courtesy: University Hospital Freiburg

Funtional imaging

BOLD imaging showing functional brain activation

Neurology

High resolution brain imaging at the microscopic level

Microbial Infection

Detection of Inflammation induced myeloperoxidase activity after Microbial Infection. Luminescent Detection of Inflammation with X-Ray overlay

Inflammation

Non invasive imaging of inflammation induced myeloperoxidase activity by i.p. injection of nutraceuticals using luminol sodium salt

Inflammation

Volume measurement of limb lesion in mouse demonstrating the change in intracel lular/extracellular water balance. (Courtesy of J Zheng, STTARR (UHN), Toronto, Canada)

Skin irritation

Multimodal fluorescence and luminescence image of a skin irritation model

Inflammation

Anatomical overlay showing luminescent detection of inflammation induced myeloperoxidase activity and NIR detection of trauma induced cell death

Metabolic diseases

Segmentation of Adipose Tissue in Obesity Mouse Model

MR/optical imaging of metastasis

MR/optical imaging of metastasis from human breast cancer cells in mouse brain: Both MR contrast enhanced images and optical images enable the vizua lization of metastasis, improving data consistency. (Courtesy Matthew Leevy, University of Notre Dame, Indiana, US)

Neurology

Imaging brain hypoxia in rats using 18F-FMISO Courtesy of Prof. M.A.Pozo Instituto Pluridisciplinar Universidad Complutense de Madrid

Oncology

Protease Activation in Tumors Using NIR Probe Image courtesy of Dr. W. Matthew Leevy, NDIIF, University of Notre Dame

Oncology

18F-FDG image of a prostate cancer tumor xenograft on a rat

Oncology

Multi-modal anatomical and molecular image overlay of NIR fluorescent tumor cells and luminescent detection of inflammation induced myeloperoxidase activity

Perfusion

99mTc-MAA imaging of lung perfusion in a mouse. Courtesy of Dr. W. Matthew Leevy, NDIIF, University of Notre Dame

PET/MR imaging of flank tumor in mouse

Correlation observed between metabolic tumor hetero geneity in PET and Anatomical heterogeneity inMRI during sequential acquisition. Courtesy of U. Mahmood, P Heidari and P . Habibollahi, MGH, Boston, US

Probe development

Spectral unmixing of two NIR fluorescent probes (red and blue) and separation from gut autofluorescence (green)

Metabolic diseases

Localized spectroscopy for metabolite analysis and metabolic imaging

Susceptibility Weighted Imaging

Magnitude, SWI, and phase images in the rat brain at (50 µm)³ isotropic resolution (ex vivo). Courtesy: H. Ong, University of Vanderbilt, Nashville, USA

Whole Body Imaging

Mouse 3D whole body imaging.

Spectroscopy STEAM

STEAM localized spectroscopy in the mouse brain at 21 Tesla.

Oncology mouse tumor

Tumor growth monitoring and volume quantification in a subcutaneous prostate cancer mouse model.

Neurology mouse brain anatomical

High resolution mouse brain anatomical imaging at 21 Tesla.

Neurology mouse brain

Mouse brain imaging (ex vivo) at (80 µm)³ isotropic resolution. Courtesy: Bernard Siow, Francis Crick Institute & UCL, UK

Neurology, Ischiema

Assessment of stroke lesion in a focal ischemic rat model shows excellent correspondence between hemispheric lesion area (HLA) and histology (TCC). Courtesy: Bernard Siow, Francis Crick Institute & UCL, UK

MR Microscopy rat brain

MR microscopy in the rat brain at (33 µm)³ isotropic resolution (ex vivo). Courtesy: H. Ong, University of Vanderbilt, Nashville, USA

Functional Imaging, Optogenetical Imaging

Visualizing single deep layer venules and arterioles (A) and their BOLD fMRI signal (B, C) in an optogenetical stimulation paradigm using EPI. Courtesy: X. Yu, K. Scheffler, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany

Cardiology Imaging, Ischiema

Late Gd Enhancement (LGE) MRI in a rat myocardial infarction model. Courtesy: Bernard Siow, Francis Crick Institute & UCL, UK

Cardiology CINE rat

Assessing cardiac function with CINE imaging in a rat model. Courtesy: Bernard Siow, Francis Crick Institute & UCL, UK

Cardiology CINE intragateUTE

Self-gated cardiac CINE imaging using IntraGateUTE; ultra-short echo times and radial readout minimize turbulences and motion artifacts.

Oncology hepatic tumor

Characterization of hepatic tumour burden in an orthotopic mouse model. Courtesy: Bernard Siow, Francis Crick Institute & UCL, UK

Cardiac Imaging in Rat

CT scan Aurovist gold nanoparticle with visualization of mouse visceral structures

Cardiovascular Imaging PET CT Si78

Heart 1275 7um rec00000284 X219Y208Z491

Langendorff Apparatus

Mouse Cardiovascular Imaging

PET Insert for High Field MRI

PET Insert for High Field MRI

Rabbit Heart

Insect 0 5al 5 3um 01

Insect 0 5al 5 3um 02

Insect 0 5al 5 3um 03

Heart 1275 7um rec1

Heart 1275 7um rec2

Bat rec voi rs2 cor mip 0002

Bat rec voi rs2 cor mip 0001

Bat rec voi rs2 cor mip 0003

Bat rec voi rs2 cor mip b0000

Bat rec voi rs2 cor mip b0002

Bat rec voi rs2 cor mip b0001

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Bat rec voi RS2 Sag224

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Bone Volume Graph

Bat rec voi rs2 cor mip 0005

Bat rec voi rs2 cor mip 0004

3d bone thickness color map CTVox nobar

Bone ti screw ctvox no-frame

Compression slice 1 0N

Compression slice 2 75N

Cortical bone crossection skyscan1272

Compression slice 3 200N

Compression slice 4 fail

Cortical core cutaway

Canine tooth with metal implant and filler skyscan1275

Fullmouse 15um rec Sag1013

Rat4klong2

Fullmouse 15um rec Cor952

Human jaw coronal slice skyscan1173 27um voxel

Fullmouse 15um rec Sag1014

Implant4k longbone 4umA

Implant4k longbone 4umB

Implant4k longbone 4umC1

Bone with Ti implant 1272 XYZ

Implant4k longbone 4umC2

Implant4k longbone 4umD1

Human jaw XYZ section skyscan1173 27um voxel

Implant4k longbone 4umD2

N1405 lv1-lv2

Implant4k longbone 4umE2

Implant4k longbone 4umE1

Implant4k longbone 4umF1

Lionfish skyscan1076 MIP

Lizard skyscan 1076 35um MIP coronal

Implant4k longbone 4umF2

Lizard skyscan1076 35um MIP sagittal

Molar tooth with polymer cap coronal section skyscan1275

Invivo kneea mouse6um ir rec0000

Mouse femur exvivo scan skyscan1176 9um voxel

Mouse LV5 0710

Invivo kneea mouse6um ir rec0002

Mouse hindlimb 1176 invivo sagittal section 1