Gallery - Preclinical in vivo imaging applications - Preclinical Imaging - Widest range of imaging modalities

Contrast agent research

Contrast agent research

Use of barium sulfate contrast agent to image the GI tract with computed tomography
Angiography

Angiography

Visualization of the vascular structure in the mouse brain
Bone research

Bone research

In vivo scan of mouse hindlimb (knee) with 9 µm pixel size
Agriculture

Agriculture

Pseudocolored X-Ray Screening of Seeds for Viability
Cardiology

Cardiology

Transverse slice of a FDG PET CT overlay of the mouse heart. Image courtesy of Dr. W. Matthew Leevy, NDIIF, University of Notre Dame, Indiana, US
Cardiovascular

Cardiovascular

Full body in vivo scan of a mouse using contrast agent
Diet Control

Diet Control

PET/MR imaging of flank tumor in mouse: Correlation observed between metabolic tumor hetero geneity in PET and Anatomical heterogeneity inMRI during sequential acquisition. Courtesy of U. Mahmood, P Heidari and P . Habibollahi, MGH, Boston, US
Brain connectivity

Brain connectivity

Axial map of the major principle diffusion direction of a mouse brain enabling to investigate brain connectivity. Courtesy: University Hospital Freiburg
Funtional imaging

Funtional imaging

BOLD imaging showing functional brain activation
Neurology

Neurology

High resolution brain imaging at the microscopic level
Microbial Infection

Microbial Infection

Detection of Inflammation induced myeloperoxidase activity after Microbial Infection. Luminescent Detection of Inflammation with X-Ray overlay
Inflammation

Inflammation

Non invasive imaging of inflammation induced myeloperoxidase activity by i.p. injection of nutraceuticals using luminol sodium salt
Inflammation

Inflammation

Volume measurement of limb lesion in mouse demonstrating the change in intracel lular/extracellular water balance. (Courtesy of J Zheng, STTARR (UHN), Toronto, Canada)
Skin irritation

Skin irritation

Multimodal fluorescence and luminescence image of a skin irritation model
Inflammation

Inflammation

Anatomical overlay showing luminescent detection of inflammation induced myeloperoxidase activity and NIR detection of trauma induced cell death
Metabolic diseases

Metabolic diseases

Segmentation of Adipose Tissue in Obesity Mouse Model
MR/optical imaging of metastasis

MR/optical imaging of metastasis

MR/optical imaging of metastasis from human breast cancer cells in mouse brain: Both MR contrast enhanced images and optical images enable the vizua lization of metastasis, improving data consistency. (Courtesy Matthew Leevy, University of Notre Dame, Indiana, US)
Neurology

Neurology

Imaging brain hypoxia in rats using 18F-FMISO Courtesy of Prof. M.A.Pozo Instituto Pluridisciplinar Universidad Complutense de Madrid
Oncology

Oncology

Protease Activation in Tumors Using NIR Probe Image courtesy of Dr. W. Matthew Leevy, NDIIF, University of Notre Dame
Oncology

Oncology

18F-FDG image of a prostate cancer tumor xenograft on a rat
Oncology

Oncology

Multi-modal anatomical and molecular image overlay of NIR fluorescent tumor cells and luminescent detection of inflammation induced myeloperoxidase activity
Perfusion

Perfusion

99mTc-MAA imaging of lung perfusion in a mouse. Courtesy of Dr. W. Matthew Leevy, NDIIF, University of Notre Dame
PET/MR imaging of flank tumor in mouse

PET/MR imaging of flank tumor in mouse

Correlation observed between metabolic tumor hetero geneity in PET and Anatomical heterogeneity inMRI during sequential acquisition. Courtesy of U. Mahmood, P Heidari and P . Habibollahi, MGH, Boston, US
Probe development

Probe development

Spectral unmixing of two NIR fluorescent probes (red and blue) and separation from gut autofluorescence (green)
Metabolic diseases

Metabolic diseases

Localized spectroscopy for metabolite analysis and metabolic imaging
Susceptibility Weighted Imaging

Susceptibility Weighted Imaging

Magnitude, SWI, and phase images in the rat brain at (50 µm)³ isotropic resolution (ex vivo). Courtesy: H. Ong, University of Vanderbilt, Nashville, USA
Whole Body Imaging

Whole Body Imaging

Mouse 3D whole body imaging.
Spectroscopy STEAM

Spectroscopy STEAM

STEAM localized spectroscopy in the mouse brain at 21 Tesla.
Oncology mouse tumor

Oncology mouse tumor

Tumor growth monitoring and volume quantification in a subcutaneous prostate cancer mouse model.
Neurology mouse brain anatomical

Neurology mouse brain anatomical

High resolution mouse brain anatomical imaging at 21 Tesla.
Neurology mouse brain

Neurology mouse brain

Mouse brain imaging (ex vivo) at (80 µm)³ isotropic resolution. Courtesy: Bernard Siow, Francis Crick Institute & UCL, UK
Neurology, Ischiema

Neurology, Ischiema

Assessment of stroke lesion in a focal ischemic rat model shows excellent correspondence between hemispheric lesion area (HLA) and histology (TCC). Courtesy: Bernard Siow, Francis Crick Institute & UCL, UK
MR Microscopy rat brain

MR Microscopy rat brain

MR microscopy in the rat brain at (33 µm)³ isotropic resolution (ex vivo). Courtesy: H. Ong, University of Vanderbilt, Nashville, USA
Functional Imaging, Optogenetical Imaging

Functional Imaging, Optogenetical Imaging

Visualizing single deep layer venules and arterioles (A) and their BOLD fMRI signal (B, C) in an optogenetical stimulation paradigm using EPI. Courtesy: X. Yu, K. Scheffler, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany
Cardiology Imaging, Ischiema

Cardiology Imaging, Ischiema

Late Gd Enhancement (LGE) MRI in a rat myocardial infarction model. Courtesy: Bernard Siow, Francis Crick Institute & UCL, UK
Cardiology CINE rat

Cardiology CINE rat

Assessing cardiac function with CINE imaging in a rat model. Courtesy: Bernard Siow, Francis Crick Institute & UCL, UK
Cardiology CINE intragateUTE

Cardiology CINE intragateUTE

Self-gated cardiac CINE imaging using IntraGateUTE; ultra-short echo times and radial readout minimize turbulences and motion artifacts.
Oncology hepatic tumor

Oncology hepatic tumor

Characterization of hepatic tumour burden in an orthotopic mouse model. Courtesy: Bernard Siow, Francis Crick Institute & UCL, UK

Preclinical In Vivo Imaging

Contrast agent research

Angiography

Bone research

Agriculture

Cardiology

Cardiovascular

Diet Control

Brain connectivity

Funtional imaging

Neurology

Microbial Infection

Inflammation

Inflammation

Skin irritation

Inflammation

Metabolic diseases

MR/optical imaging of metastasis

Neurology

Oncology

Oncology

Oncology

Perfusion

PET/MR imaging of flank tumor in mouse

Probe development

Metabolic diseases

Susceptibility Weighted Imaging

Whole Body Imaging

Spectroscopy STEAM

Oncology mouse tumor

Neurology mouse brain anatomical

Neurology mouse brain

Neurology, Ischiema

MR Microscopy rat brain

Functional Imaging, Optogenetical Imaging

Cardiology Imaging, Ischiema

Cardiology CINE rat

Cardiology CINE intragateUTE

Oncology hepatic tumor