software, APEX2, PROTEUM2, single crystal X-ray diffraction

The Reactivity of Lithium Organics – A Contribution from a Charge Density Study

SC-XRD Application Note

Reactivity of Lithium Organics App Note, SC-XRD

Lithium organic compounds have gained in importance ever since their discovery. Today they are indispensable reagents in organic as well as inorganic syntheses. They are readily applied in various preparative protocols, ranging from deprotonation of weakly acidic reagents to bond formation in organic group transfers as well as in industrial large-scale anionic polymerisation reactions. The structure-reactivity-relationship is still the Holy Grail to be found in this class of compounds as it is commonly accepted that the lithiated species determine the composition, yield and stereo-chemistry of the product.

Charge density investigations can provide insight into the bonding and reactivity of these labile molecules.