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▶ Watch On-Demand | 54 Minutes

On-Demand Sessions: dSTORM Imaging of Neuronal GABAAR Spatial Patterning Regulated by GABA and Astrocytic Cholesterol

See how super-resolution microscopy techniques are enhancing our understanding of cellular neuroscience. 
Watch Now | 34 Minutes

GABA and Astrocyic Cholesterol regulate Neuronal GABaR Spatial Patterning

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Presented by Zixuan Yuan, Ph.D., Postdoctoral Fellow, Nedergaard lab, University of Rochester (June 11, 2025)

       PRESENTATION HIGHLIGHTS:

  • [00:02:27] Spatial biochemistry of the plasma membrane
  • [00:06:53] Where is GABAAR on the membrane?
  • [00:10:32] Does GABAAR move on the membrane?
  • [00:15:48] Does the lipid environment affect GABAAR movement?
  • [00:25:48] What's the meaning of GABAAR moving?
  • [00:31:22] Summary
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Q&A

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       PRESENTATION HIGHLIGHTS:

  • [00:01:31] Which fluorescence dye are you using for your dSTORM experiment?
  • [00:02:53] What is the level of colocalization of GM1 with synaptic sites and post-synaptic scaffolds? 
  • [00:04:08] Any specific Vutara features that helped you with your research?
  • [00:09:34] Did you look at synaptic inhibition and measure miniature inhibitory synaptic currents?
  • ...

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