Library Synthesis and Reaction Screening
with Online Benchtop NMR
synthesis and reaction screening. Unlock new chemical spaces, enhance efficiency, and achieve
reproducible results with seamless NMR integration.
Precision Meets Innovation in Every Experiment
Meeting the increasing demand for innovative medicines, FLEX ISYNTH and Fourier 80 benchtop NMR enable unique chemical exploration, enhance productivity, and deliver seamless automation to tackle your most complex challenges.
Workflow
Optimize your workflows with FLEX ISYNTH’s fully automated solutions. From inertization to gravimetric dispensing, heating, sampling, and real-time NMR integration, every step is designed to streamline and accelerate your chemical processes, ensuring precise, consistent results across diverse applications.
Synthesis and Benchtop Online NMR
Benefits
- Accelerate workflows with automated, parallel synthesis
- Enhance productivity by up to 100x compared to manual processes
- Reduce barriers to innovative chemistry with versatile configurations
- Optimize reaction screening with advanced online NMR analytics
- Improve reproducibility and consistency across experiments
Applications
- Medicinal chemistry molecule discovery
- High-throughput reaction optimization
- Parallel synthesis of libraries for drug development
- Characterization of reaction pathways and intermediates
- Screening novel routes for synthesis
Comprehensive Features and Advantages of FLEX ISYNTH
| Key Advantage / Feature | Description |
|---|---|
| Fully automated system | Integrated reaction preparation, synthesis, work-up, analysis, and output to storage vials for both solid- and liquid-phase library synthesis and reaction screening |
| High-precision glass reactor arrays | Easy-to-use, disposable, multifunctional arrays with reaction scales from μL to mL |
| Screwless, self-sealing reactor design | Supports mixing by shaking (up to 1,000 rpm), heating (up to 150°C), cooling (-20°C), refluxing, vacuum, inertization, evaporation, L/L extraction, filtration, solid-phase extraction, crystallization, and drying |
| Proprietary robotic tool exchange | Ensures flexibility in automation |
| Gravimetric solid handling | Handles solids from μg to g |
| Gravimetric liquid handling | Handles liquids from mg to g and μL to mL |
| Proven liquid handling | Includes pH adjustment, filtration, and heated needle extension |
| Hight throughput | Supports 24 / 48 / 96 / more parallel reactions per run |
| Integrated analytics | Includes benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR / MIR / DLS measurement cell |
| Safety and conditioning | Ventilated hood ensures safe and conditioned operation |
| AUTOSUITE Software | Drag-and-drop experimentation with integration to LIMS, ELN, data analysis, and AI/ML closed loop |
| Benchtop NMR integration | Includes NMR devices (e.g., Bruker Fourier Rxn Lite) with 80 MHz operating frequencies |
| NMR capabilities | Supports 1D and 2D spectra, sample injection, flow cell and standard 5 mm sample tube options, permanent magnet (no liquid nitrogen/helium), and a 2 Gauss line within the device housing |
Stay Ahead with Our Expert-Led Webinars
Register our webinars to gain insights from industry experts on the latest advancements in laboratory automation, analytical techniques, and scientific research. Enhance your knowledge and stay updated with cutting-edge developments and discover how integrated lab automation and digitalization solutions seamlessly integrate instruments and workflows to redefine research and testing.
Testimonials
Accelerating Discovery: Automation Meets Benchtop NMR
Interview with Dr. Jean-François Ayme, University of Liverpool
Discover how automation and benchtop NMR are transforming synthetic chemistry workflows in this exclusive interview with Dr. Jean-François Ayme, Research Coordinator at the University of Liverpool. Learn how the integration of Chemspeed’s automation platform with the Fourier 80 enables high-throughput experimentation, standardized data collection, and AI-driven insights paving the way for faster, smarter chemical innovation.
Automated Lab: Automating Chemistry with Intelligence
Interview with Dr. Sriram Vijayakrishnan, University of Liverpool
In this insightful interview, Dr. Sriram Vijayakrishnan shares how mobile robots, benchtop NMR, and AI-driven automation are reshaping synthetic chemistry.
Discover how closed-loop organic synthesis and integrated analytical techniques are enabling smarter, safer, and more sustainable workflows.
Bringing lab automation closer to human decision-making than ever before.
Smarter Chemistry: AI and Automation in Drug Discovery
Interview with Lyubomir Kotopanov, University of Liverpool
In this interview, PhD student Lyubomir Kotopanov shares how automation and benchtop NMR are accelerating drug discovery at the University of Liverpool.
Learn how standardized data generation, AI integration, and real-time reaction monitoring are transforming organic synthesis workflows and uncover how unexpected results can lead to new scientific breakthroughs.
