PAT-Driven Real-Time Reaction Monitoring by Integrating synTQ with Bruker’s Fourier 80 Benchtop NMR
 PAT-Driven Real-Time Reaction Monitoring by Integrating synTQ with Bruker’s Fourier 80 Benchtop NMR
Application - Magnetic Resonance

PAT-Driven Real-Time Reaction Monitoring by Integrating synTQ with Bruker’s Fourier 80 Benchtop NMR

In modern pharmaceutical development and manufacturing, the ability to monitor reactions in real time and respond dynamically to changes in process conditions through Process Analytical Technology (PAT) is increasingly seen as both a scientific necessity and a regulatory imperative. The integration of real-time analytical techniques with process control systems is a key enabler for the implementation of PAT and Quality by Design (QbD) frameworks in pharmaceutical manufacturing. This application note describes the coupling of Bruker’s Fourier 80 benchtop Nuclear Magnetic Resonance (NMR) spectrometer with a PAT software platform to achieve continuous, on-line and in-line reaction monitoring and automated control. This study highlights the potential of benchtop NMR as a practical, information-rich PAT tool that can help enhance process understanding, control and automation in pharmaceutical development and production environments.

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