MALDI Basic Webinar

Matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) is a cornerstone analytical technique in life sciences, material characterization and diagnostic medicine. Over the years, Bruker’s commitment to MALDI technology has driven breakthroughs in performance and enabling novel applications across diverse research fields. In this webinar, we will revisit the fundamental principles of MALDI-MS, and explore the latest applications in MALDI-imaging, polymer analysis and introduce Bruker’s newest MALDI-MS, the neofleX.

Key Leaning Objectives

• Learn the core principles MALDI Mass Spectrometers
• Explore the capabilities MS-Imaging with MALDI-MS
• Learn about best practices of Polymer Analysis Using MALDI-MS
• Discover the features of Bruker’s newest MALDI-MS platform, the neofleX

Who should attend

• Researchers and analysts who use mass spectrometers and want to revisit the basics of MALDI-MS
• Professionals considering the adoption of new mass spectrometry technologies
• Anyone interested in exploring applications of MALDI-MS
• Scientists working with synthetic polymers
• Individuals curious about imaging analysis using MALDI-MS
• Teams or individuals considering in-house training on MALDI technology

Duration time: 1 hour 35 minutes

Introduction to Bruker's New MALDI-TOF/MS Product: neofleX

Fundamentals of MALDI Mass Spectrometry
This session provides a foundational explanation of ionization by MALDI and the principles and overview of MALDI mass spectrometers.

Imaging by MALDI Mass Spectrometry
This session covers the mechanism of MALDI-imaging, along with the current and latest applications. MALDI-imaging leverages the inherent quality of MALDI as a surface analysis technique by scanning across the surface of a sample in discrete position. Compounds from the sample surface at each position are ionized and detected generating distinct mass spectrum, which are collated and visualized as detailed ion images. Targeted compounds such as drug molecules and their metabolites can be visualized, while untargeted analysis and integration of multi-omics datasets of lipids, metabolites and targeted protein enables biomarker discovery.

Polymer Analysis by MALDI Mass Spectrometry
MALDI mass spectrometry is also used for analyzing synthetic polymers. Its gentle ionization allows analysis without fragmenting polymer molecules. It can provide detailed information unattainable by other methods by leveraging its features, which include simple spectra, wide mass range, and high mass resolution. We will introduce the fundamentals of spectral analysis, dedicated software, and practical examples.