Dynamis DNP

In NMR spectroscopy, dissolution DNP with the Dynamis enables researchers to detect low-abundance nuclei, dilute species, and transient chemical intermediates for startling insights on previously intractable problems.  Dynamis DNP’s rapid polarization and simple automated workflows allow analysis of complex biological or chemical samples in ultrasensitive solution NMR spectra. This makes it a powerful tool for structural biology, metabolomics, and dynamic studies of protein-ligand interactions. Driven by the TopPol interface, full d-DNP workflows are carried out with ease and precision, while advanced users benefit from the full RF control and customization available with TopSpin.

For preclinical MRI, dissolution DNP unlocks real-time metabolic imaging with hyperpolarized tracers, offering new insights into disease progression and therapeutic response. From cardiac metabolism to tumor mapping and brain imaging in glioma and TBI models, the Dynamis DNP enables voxel-by-voxel metabolic quantification with high temporal resolution. Bruker MRI platforms are ideally suited to utilize the power of the Dynamis in a seamlessly integrated package for groundbreaking translational research.

Powerful: > 30,000 signal gains from 40% polarization

Fast: CP-driven DNP for rapid, uncompromised hyperpolarization

Broadly Applicable: With many imaging agents and complex mixtures

Sustainable: Zero-consumption cryogenics (no helium refills)

Flexible: Dual-mode operation (CP-driven and direct DNP)

Simple: TopPol software for automated experiment control

• Preset operations for CP / TEMPOL and direct / trityl radical polarizing agents
• Automated optimizations for custom radicals (microwave frequency sweeps and power dependence)

Effective: Efficient automated sample handling (5-250 µL) and cleaning

Reliable: Designed for easy, reproducible and robust operation

Metabolomics

Unlock real-time insights into cellular metabolism with hyperpolarized NMR and MRI. The Dynamis DNP system enables detection of dilute, natural-abundance metabolites, supporting research in chronic kidney disease (CKD), diabetes, and metabolic disorders. Its rapid polarization and single-scan sensitivity make it ideal for time-sensitive metabolic profiling.

Cancer Research

Visualize tumor metabolism and therapeutic response with unprecedented clarity. DNP-enhanced MRI allows for non-invasive mapping of metabolic fluxes in vivo, aiding in the identification of biomarkers and the evaluation of treatment efficacy. Applications include tumor hypoxia, glycolysis, and lactate production studies.

Neuroscience

Advance understanding of brain metabolism in health and disease. The Dynamis DNP system supports high-resolution imaging of cerebral metabolic pathways, enabling research into glioma, traumatic brain injury (TBI), and neurodegenerative diseases. Its compatibility with preclinical MRI platforms ensures translational relevance.

Protein Structure & Enzyme Dynamics

Enhance NMR studies of protein-ligand interactions, folding, and conformational changes. DNP provides the sensitivity needed to study low-concentration samples and transient states, accelerating structural biology research and drug discovery.

Cardiac Imaging

Capture dynamic cardiac metabolism in real time. DNP-enhanced MRI enables voxel-by-voxel quantification of metabolic substrates in preclinical models, supporting research into ischemia, heart failure, and cardiomyopathies.

Translational & Preclinical Imaging

Bridge the gap between bench and bedside. The system’s dual compatibility with NMR and MRI allows researchers to track molecular processes across modalities, supporting translational studies in personalized medicine, pharmacokinetics, and disease progression.