Light-Sheet Microscope Optimized for Long-Term 3D Fluorescence Imaging

Key Features

  • Close-to-natural environmental conditions for sensitive samples
  • Compact, vibration-free and robust design
  • Resolution down to 255 nm in xy
  • Browser-based user interface

Product Overview

Dedicated to live imaging, the Luxendo InVi SPIM is a microscope that has been optimized for long-term 3D fluorescence imaging of living specimens.

Easy access to the sample chamber, precisely controlled environmental conditions, maximized photo-efficiency, and short illumination times enable long-term imaging without harming live specimens. The minimization of required specimen medium further leverages its functionality.

The optical configuration combined with the fast acquisition speed of the InVi SPIM enables 3D reconstruction, tracking of cellular and subcellular positions, and morphological analysis in real time.

Typical applications of the microscope include in toto imaging of small animal models such as whole mouse embryos, Zebrafish and Drosophila embryos, imaging of dynamic processes in mammalian cell culture applications, and even live imaging of intact and living plant models.

Adding a choice of various beam patterns – classical static Gaussian light-sheets, scanned Gaussian beams, Bessel beams and optical lattices, or even customized shapes – provides unique flexibility to optimize your bioimaging experiments.

Some versions are not available in Germany.

InVi SPIM Platform

The InVi SPIM’s compact, vibration-free and robust design provides maximal stability during your long-term experiments.

Tailored to fit your lab bench, this class 1 laser system does not require any air table or vibration compensation mechanism as all moving components are light-weighted and balanced with the motor technology. Maximal stability of focus and thermal conditions are also guaranteed. The proprietary piezo crawler stages ensure longevity and precision for a permanently accurate specimen positioning. Neither the images nor the natural growth behaviour of your sample are affected by the gentle image recording.

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Compact, vibration-free and robust design for long-term experiments


The InVi SPIM is the first commercially available inverted light-sheet microscope.

It is perfectly suited for a great variety of samples and applications ranging from cell culture to whole embryos (e.g. Drosophila and Zebrafish).

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InVi SPIM Lattice Pro

The Advanced Illumination Module (AIM) is a modular extension of the InVi SPIM that provides the highest level of flexibility for illuminating your sample with a light-sheet.

It expands the capabilities of the InVi SPIM: while maintaining the ease-of-use and stability of the system, it adds tailorable, interactive adaptability of the beam shape to suit the highly specific requirements of your sample. You choose what gives you the best results for your 3D high resolution imaging experiment – large field of view, high speed or optimal spatial resolution.

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Tailor the beam shape to suit the specific requirements of your sample