Metabomeeting

Bruker's Lunch Seminar at MetaboMeeting 2018

December 17-19, 2018 in Nottingham, UK

Registration

You are cordially invited to join the Bruker Lunch Seminar
“Metabolomics – Deeper insights by turning data into knowledge” at the MetaboMeeting 2018.

To participate at the seminar please register via the form below.

Please also visit our booth #2 at the exhibition and meet our specialists for deeper discussions.

We are looking forward to seeing you in Nottingham,

Your Bruker Daltonics Team

Program

December 18, 2018, 1:00pm

To address the typical challenges in Metabolomics research, sensitive and robust analytical instrumentation and software need to be seamlessly integrated to provide high quality data for biological interpretation. This Lunch Seminar will present latest examples for targeted and non-targeted metabolomics using Bruker’s unique NMR- and MS-solutions and placing the results into the biological context - moving from structure to function.

Overview of Bruker Metabolomics NMR-based Screening Solutions

An overview will be given on the metabolomics based NMR screening solutions, ranging from food quality, authenticity and fraud detection on different matrices to clinical/translational research including biobank QC. The need for standardization on all matrices will be demonstrated, stringent validation of quantification and statistical tools is explained. Integrated use of NMR and Mass spectrometry platforms is advantageous in solving metabolic pathway involvement as well as in the identification of unknown signals in bodyfluid spectra are discussed. The potential of statistical Heterospectroscopy (SHY)  is examplified. An outlook will be given on future screening matrices as well on a feasibility using bloodspots instead of plasma or serum samples.

Dr. Manfred Spraul, CTO AIC Division, Bruker BioSpin, Rheinstetten, Germany

Novel and innovative Solutions for advancing Metabolomics and Lipidomics Research

In this workshop we will present novel solutions to address the typical bottlenecks in metabolomics and lipidomics research.
One topic will be FIA-MRMS (Flow Injection Analysis - Magnetic Resonance Mass spectrometry): a chromatography-free approach to address sample throughput needs for analyzing large cohorts of samples for example in clinical and phenomics research. This workflow is driven by the extreme resolution of magnetic resonance mass spectrometry and enables to analyze over 200 samples a day.
 
Furthermore, we will demonstrate our workflows for TIMS (Trapped Ion Mobility Spectrometry) separated metabolomics and lipidomics samples. The TIMS technology enables the exact measurement of collisional cross section (CCS) values at a very high reproducibility and TIMS resolving power. These values are specific properties for any ion species under given conditions. Therefore, acquired values can be used for increased confidence in the identification of target compounds. A novel tool for the prediction of lipid CCS values is fully integrated in the MetaboScape 4.0 software. Based on a machine learning approach to cover a wide range of lipid structures, predicted CCS values can be compared with the ones measured on a Bruker timsTOF and timsTOF Pro instrument. This feature, together with the option to use CCS libraries in MetaboScape increases the speed and confidence in the de-replication process.

Dr. Sven Meyer, Solutions Development OMICs, Bruker Daltonik, Bremen, Germany

For further information, please contact:

Anne Kropp
Bruker Daltonik GmbH
Fahrenheitstrasse 4
28359 Bremen
Germany
anne.kropp@bruker.com

Venue Info
University of Birmingham
Aston Webb Great Hall Block
Great Hall
Birmingham, B15 2 TT
UK
Website

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Dear Customer,

Thank you very much for your registration. We have reserved a place for you and are looking forward to seeing you in Birmingham.


Kind regards,
Your Bruker Sales & Marketing Team