NMR & EPR Pharma Solutions

InsightMR

Designed to monitor reactions, enhance reaction understanding, gain confidence when transferring processes from lab to plant. 

Faits marquants

New NMR Methods for Reaction Monitoring

Designed for the analysis of chemical and bioprocesses by NMR, InsightMR portfolio is ideal for both industrial and academic scientists studying, optimizing and controlling reactions. InsightMR’s two components, a flow unit and dedicated software, enable online monitoring of (bio)chemical reactions in real-time under real process conditions.

Gathering insights into the mechanism and kinetics of chemical reactions is now at your fingertips!

  • Provides answers to key chemical questions: reaction yield, mechanistic insights and reaction kinetics
  • Harness NMR data to make strategic process chemistry decisions, ultimately leading to cost savings.

Caractéristiques

Features

InsightMR Flow Unit

Design for on-line reaction monitoring by NMR, InsightMR flow unit enables simultaneous acquisition of data using different analytical techniques (NMR, IR, pH, and MS) and captures the start of the reaction.

InsightMR for Fourier RxnLab

  • Temperature controlled transfer lines: 25 to 60 °C capability
  • Flow-through flow unit, based on industry tested well established InsightMR™ design
  • Access to spectra deconvolution, predictions,  chemometric and database tools
  • Compatible with the use of the Fourier 80 PAL sample changer (max. sample capacity of 120)
  • Tested to withstand pressures over 10 bar
  • InsightMR 2.0 software
  • Interchangeable glass tube. Proven robustness – industry tested.

 

InsightMR for High Field NMR

  • Temperature controlled transfer lines: -20 to 120 °C capability
  • Tested to withstand pressures over 10 bar
  • Interchangeable glass tube. Proven robustness - industry tested
  • Compatible with all Bruker sample changers
  • 3- or 5-mm (Room Temperature and Cryo) Probes
  • InsightMR 2.0 software.
InsightMR for Fourier 80 flow unit
Fourier RnxLab
InsightMR - Workflow video
InsigthMR flow unit

InsightMR 2.0 Software

InsightMR software is a platform designed for the analysis of chemical processes by on-line NMR. Integrated acquisition control and data processing features enable on-the-fly acquisition parameter adjustment based on real-time kinetic data.

  • Straightforward data acquisition with on-the –fly visualisation of build-up curves. Default experiments provided for both deuterated and non-deuterated solvents
  • Rapid and effortless handling of hundreds of stacked spectra
  • Supports acquisition, processing and analysis of series of 1Ds (different nuclei), interleaved experiments and multi samples in parallel
  • Automatic seamless transfer of spectra to Mnova reaction monitoring Workstation (e.g. phase, baseline and GSD)
  • Access to database, prediction, assignment and chemometrics tools
  • Results are delivered as kinetic, and waterfall plots ready to report and/or export.

Avantages

Benefits

  • On-the-fly quantitative build-up curves without the need of tedious calibration steps 
  • Structural information for reagents, (bi)products and intermediates 
  • Reduced risk with direct knowledge transfer from high-field NMR (understanding) to low-field benchtop (control)
  • Increased selectivity, resolution and sensitivity compared to vibrational spectroscopy
  • Used also to calibrate other techniques
  • Straightforward installation and operation with minimal learning curve
  • Affordable and with minimal cost of ownership
  • Bringing NMR to the (bio)reactor

Applications

Webinaires

Témoignages

Testimonials

Celebrating the Opening of the Dynamic Reaction Monitoring Facility

The Advantages of Reaction Monitoring by NMR at Pfizer

Understanding Catalysis with Flow NMR -Magnetic Resonance - NMR

Support

Labscape

Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory