Nuclear Molecular Imaging

PET/CT Si78

The PET/CT Si78 is a high throughput imaging instrument, dedicated for drug and tracer development for clinical translation . It combines highest PET sensitivity with fast and low dose CT.

Quantity and Quality

Hand in hand

Faits marquants

From Bench to Bed

Fast translation of preclinical tracers

6 mGy

Low X-ray Dose for longitudinal studies

80 x 150 mm

Total Body PET FOV High PET resolution with highest sensitivity

Si78 PET/CT Brochure

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Highlights

The PET/CT Si78 is a molecular imaging system for sequential Positron Emission Tomography (PET) and X-Ray Microtomography (uCT). The fully shielded scanner, the animal welfare solutions and the experimental workflows are designed to support high throughput translational preclinical research in all field s of nuclear molecular imaging research.

ParaVision 360 software offers the complete solutions from subject & study handling, to scan execution, image reconstruction co-registration & image fusion, data analysis and automatic report generation. It easily links imaging data to the most advanced quantitative PET data analysis and kinetic modelling features offered by the PMOD biomedical image quantification software of Bruker.

Caractéristiques

Features

Instrument:

ParaVision® 360 preclinical imaging software suite for scan planning, image reconstruction, visualization, image analysis and data/scan/subject databases
Touch screen and camera for easy animal positioning and scanner control
Fully automated high precision motorized animal transport system for precise animal positioning and automatic image co-registration and fusion
Direct access to the gantry from both sides with minimum distance to the PET FOV enables direct tracer application in kinetic tracer studies
PMOD software tools for advanced data analysis and quantification
Fully X-ray shielded during CT scanning
165 x 95 x 240 cm instrument size

PET Features

Up to 0.7 mm spatial resolution
Up to 12 % sensitivity
150 x 80 mm FOV
True DOI, no loss of resolution across FOV
Ultrafast GPU reconstruction (MLEM, OSEM and MAP)

CT Features

52 µm resolution
80 (200) x 80 mm FOV single (multiple) bed positions
Gated cardiac imaging
Patented 2-5 x dose reduction

Animal Welfare

Single click - self connect animal cradles for mice and rats
Multi-mouse animal cradles
Animal monitoring and warming system
Preparation Stand

Applications

Range of CT only Applications: Rabbits

Skull Ex-vivo: Bone Density, Orthopedics, Metabolism

Range of CT only Applications:
Mice Pulmonary

Oncology, Fibrosis, Emphysema

Cardiovascular Imaging

Normal mouse 4 slice coronal plane PET/CT 18FDG heart right ventricle clearly resolved MicroCT (200 µm) with lung and heart shadow

Total Body PET Capabilities

Total body PET represents a unique capability for studying the biodistribution and kinetics of candidate tracers. The example above shows the results of one single FDG PET/CT acquisition with the Si78 with a 20 min dynamic PET acquisition and a 10 second CT acquisition.

Neuroimaging in Rats

18FDG PET/CT of healthy rat with metabolic activity of cerebral cortex, Harderian glands, and jaw muscles clearly resolved. MicroCT (50 µm) well defined skull, sinuses, and jaw structures

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Plus d'informations

More information

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More Information on PET/CT SI78 and Applications:

Brochures

Application Notes

Support

Labscape

Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory