FlashNote: Metabolomics workflows? Sustainability please!
Non-targeted data processing in metabolomics is a time consuming task. It is often unavoidable to find yourself lost in a forest of peaks, wondering what is important – and more critically how you can find it. Eventually, a more effective workflow with tools like statistical treatment, annotation, and data base interrogation can be established – which can be...
Non-targeted data processing in metabolomics is a time consuming task. It is often unavoidable to find yourself lost in a forest of peaks, wondering what is important – and more critically how you can find it. Eventually, a more effective workflow with tools like statistical treatment, annotation, and data base interrogation can be established – which can be quite a relief. So when a beloved tool of your pipeline gets withdrawn or discontinued, it can be a serious setback. Thankfully, with Bruker's MetaboScape® software, you get the best of both worlds: Open source flexibility and trusted sustainability!
Back
Poster Note: Fully Automated Robotic Set Up, 02-2016
The activity of most therapeutic antibodies is directed by their ability to link to a target antigen. Localizing the amino acids (AAs) responsible for this interaction is mandatory from a mechanistic point of view, but also for intellectual property protection. Epitope mapping is performed with an array of techniques, including hydrogen exchange mass...
The activity of most therapeutic antibodies is directed by their ability to link to a target antigen. Localizing the amino acids (AAs) responsible for this interaction is mandatory from a mechanistic point of view, but also for intellectual property protection. Epitope mapping is performed with an array of techniques, including hydrogen exchange mass spectrometry (HX-MS). With HX-MS solvent accessibility of the polypeptide backbone is measured and related to the proteins secondary structureas well as monitoring conformational changes occurring during antigen binding.
Back
App Note: LCMS-78 Automated Analysis of Protein Sequence Variants, 12-2012 (8704819)
Here we describe an automated UPLC-MS based method for the analysis and quality confirmation of the intact mass for protein sequence variants. The automated workflow is implemented using Bruker Daltonics’ Biopharma CompassTM software which allows for data acquisition, processing and
analysis to occur with minimal user intervention.
Here we describe an automated UPLC-MS based method for the analysis and quality confirmation of the intact mass for protein sequence variants. The automated workflow is implemented using Bruker Daltonics’ Biopharma CompassTM software which allows for data acquisition, processing and
analysis to occur with minimal user intervention.
Back
App Note: LCMS-92 Toxtyper Interlaboratory Tests, 04-2014 (1828632)
AbstractThere is high demand in clinical research and forensic toxicology for comprehensive, specific and transferable techniques that overcome the well-known limitations of current GC-MS, LC-UV/DAD and immunoassay solutions.
AbstractThere is high demand in clinical research and forensic toxicology for comprehensive, specific and transferable techniques that overcome the well-known limitations of current GC-MS, LC-UV/DAD and immunoassay solutions.
Back
