Further reading about flexImaging

Poster Note: Fully Automated Robotic Set Up, 02-2016

The activity of most therapeutic antibodies is directed by their ability to link to a target antigen. Localizing the amino acids (AAs) responsible for this interaction is mandatory from a mechanistic point of view, but also for intellectual property protection. Epitope mapping is performed with an array of techniques, including hydrogen exchange mass...     

The activity of most therapeutic antibodies is directed by their ability to link to a target antigen. Localizing the amino acids (AAs) responsible for this interaction is mandatory from a mechanistic point of view, but also for intellectual property protection. Epitope mapping is performed with an array of techniques, including hydrogen exchange mass spectrometry (HX-MS). With HX-MS solvent accessibility of the polypeptide backbone is measured and related to the proteins secondary structureas well as monitoring conformational changes occurring during antigen binding. Back

App Note: LCMS-78 Automated Analysis of Protein Sequence Variants, 12-2012 (8704819)

Here we describe an automated UPLC-MS based method for the analysis and quality confirmation of the intact mass for protein sequence variants. The automated workflow is implemented using Bruker Daltonics’ Biopharma CompassTM software which allows for data acquisition, processing and analysis to occur with minimal user intervention.

Here we describe an automated UPLC-MS based method for the analysis and quality confirmation of the intact mass for protein sequence variants. The automated workflow is implemented using Bruker Daltonics’ Biopharma CompassTM software which allows for data acquisition, processing and analysis to occur with minimal user intervention. Back

App Note: LCMS-92 Toxtyper Interlaboratory Tests, 04-2014 (1828632)

AbstractThere is high demand in clinical research and forensic toxicology for comprehensive, specific and transferable techniques that overcome the well-known limitations of current GC-MS, LC-UV/DAD and immunoassay solutions.

AbstractThere is high demand in clinical research and forensic toxicology for comprehensive, specific and transferable techniques that overcome the well-known limitations of current GC-MS, LC-UV/DAD and immunoassay solutions. Back

App Note: LCMS-91 Toxtyper - a Comprehensive LC-MSn application for Clinical Research and Forensic Toxicology, 04-2014 (1828629)

AbstractA major task for toxicology research is the reliable, fast and comprehensive identification of drugs and drugs of abuse (DOA). Current techniques such as GC-MS, LC-UV/DAD and immunoassays have several limitations. Liquid chromatography tandem

AbstractA major task for toxicology research is the reliable, fast and comprehensive identification of drugs and drugs of abuse (DOA). Current techniques such as GC-MS, LC-UV/DAD and immunoassays have several limitations. Liquid chromatography tandem Back

App Note: CA-1822322 Immunosuppressant drugs by EVOQ Elite, 04-2014