MicroProbes (1mm TXI, 1.7mm TXI)

Small volume probes for Bio NMR Applications

Over the past few years there has been a significant growth in demand for miniaturization in all areas of modern research and development. Evoked by many exciting applications, there is a need for analytical methods which require smaller amounts of sample.


Bruker meets this challenge with a revolutionary NMR probe design: The 1mm (and 1.7mm) MicroProbe. It operates with disposable 1mm capillary sample tubes (resp. 1.7mm sample tube) and the sample volume of 5 (resp. 30) microliters enables use of the lowest amounts of sample to run all high resolution NMR experiments with outstanding sensitivity.
Due to the TXI-type probe design, the z-gradient coil and the automatic matching and tuning accessory, the 1mm MicroProbe can be used for a wide variety of NMR experiments.

The 1mm TXI MicroProbe offers the highest 1H mass sensitivity for RT probes which results in a up to 4 times higher mass sensitivity than 5mm conventional probes (with respect to the same sample amount). The 1.7mm TXI MicroProbe offers an optimal 1H and 13C mass sensitivity.



  • „„Excellent solvent suppression, with only a small amount of solvent in the active volume
  • „„Virtually no salt effect, due to the small tube  diameters
  • „„Very short pulses for all nuclei, opening up an exciting new range of applications
  • „„Discrete sample tubes:

    • Funnel for manual filling, or can be filled automatically
    • Cap to protect the sample
    • Automated sample identification with 2D matrix codes

  • 1mm TXI MicroProbe: up to 4 times higher mass sensitivity than 5mm conventional probes (with respect to the same sample amount)
  • 1.7mm TXI MicroProbe: an optimal 1H and 13C mass sensitivity
  • Excellent solvent suppression properties
  • Virtually no salt effect
  • Discrete samples in tubes that can be sealed and stored
  • Automation accessory for sample preparation and handling available

MicroProbe Accessories

The MicroProbes works with discrete, disposable 1mm sample tubes, which may be sealed after filling. The glass tubes have a plastic, v-shaped top part attached to them, which allows for easy manual sample filling even with volumes as small as 5 (resp. 30) micro liters. The tubes may be equipped with a digital matrix code on the plastic top parts, which then uniquely identifies each sample.
Even though manual sample filling is straight forward with the 1mm sample tubes, Bruker BioSpin supplies a modified version of the Gilson 215 Liquid handler which enables the fast, reliable and comfortable filling of many 1mm (resp. 1.7mm) sample tubes at a time. Here the sample tubes are arranged in the industry-standard 96 well plate format, so that the tube racks are fully compatible with all other laboratory or storage equipment which is capable to handle this format.


The sample tubes are transferred into the magnet by use of shuttle, very similar to the well known 5mm spinners. The tube does not need to be adjusted inside the shuttle since all adjustments are made automatically inside the probe. These shuttles may be used in Bruker-BioSpin’s automatic NMR sample changers such as the NMRCase and the BACS-60 or BACS-120 sample changer.


Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory

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