Come visit us in Booth 321!
December 14 - 18 | San Diego Convention Center | San Diego, CA
Meet us in San Diego, CA for the annual Cell Bio Meeting, where we’ll be showcasing our versatile and innovative solutions for life science research. Our atomic force microscopes, super-resolution microscopes, light-sheet microscopes, and quantitative phase imaging enable researchers to continuously drive advancements in cellular biology.
We invite you to connect with our experts on the expo floor and at their talks. Our team is excited to answer your questions, discuss your applications, and help you discover how Bruker’s advanced solutions can drive your research. See you there!
Conference Host:
American Society for Cell Biology (ASCB)
European Molecular Biology Organization (EMBO)
Conference Venue:
San Diego Convention Center | San Diego, CA, USA
Bruker Talks
Advancing Nanobiomechanical Research: Large Tissue Area Mapping and Nano Scale Rheology via AFM
Abstract: The expansion of atomic force microscopy (AFM) applications to encompass nanomechanical measurements across millimeter to centimeter scales, coupled with the exploration of rheological properties in the frequency domain, introduces a complex array of challenges. The inherent precision and sensitivity of AFM, tailored for atomic and nanoscale interactions, are tested as we extend its scope.
In a collaborative study with Prof. Dr. Thorsten Hugel, we explore the nanomechanical landscape of osteoarthritis (OA) on a large tissue scale. Through a novel hybrid fluorescence-AFM approach, we successfully correlated superficial chondrocyte spatial organization (SCSO) with microscale elastic modulus and identified nanoscale mechanical property variations in articular cartilage (AC). This technique enabled the precise mapping of elastic modulus variations over extensive areas of native AC, unveiling pivotal insights into the early stages of OA. By elucidating the relationship between cellular organization and mechanical alterations in tissue, our findings offer a new lens through which to view the hierarchical structure of biological tissues such as cartilage.
This research underscores the critical role of Smart Mapping and nano-scale rheology within the AFM framework, providing a fresh perspective on the biomechanical study of hierarchical biological tissues. These technological advancements are instrumental in enhancing early OA diagnosis and hold the potential to inform the development of hierarchical biomaterials. Ultimately, our work lays the foundation for innovative treatment strategies for OA and similar pathologies, marking a significant leap forward in nanobiomechanical research.
Date: Monday, December 16
Time: 10:15am – 11:00am
Location: Meeting Room 22
Level: Intermediate
Speaker: Ming Ye
Unveiling Sub-Cellular Mysteries with the Bruker Vutara VXL
Abstract: The Bruker Vutara VXL, a single-molecule localization microscope (SMLM), transcends the optical resolution limit of traditional fluorescence microscopy, achieving resolutions of 20 nm and beyond. Its unique bi-plane technology enables precise 3D imaging and tracking within biological samples, from cell cultures to tissue sections, without TIRF. This system is particularly adept at collecting 3D z-stacks in thick samples, providing unparalleled insights into cellular structures, molecular machines, and chromosomal configurations.
The Vutara VXL’s dual-camera module facilitates simultaneous multi-color imaging, enhancing the ability to study complex biological processes in real-time. Integrated fluidics support multiplexed imaging techniques such as DNA-PAINT, chromatin tracing, and smFISH, allowing for a comprehensive spatial and temporal analysis of sub-cellular components. This in-depth analysis provides a wealth of insights into the dynamics of cellular processes. The powerful yet user-friendly software streamlines experimental workflows and data analysis, making advanced microscopy accessible to researchers.
This presentation will highlight the capabilities of the Bruker Vutara VXL in pushing the boundaries of cell biology research. Attendees will learn how this compact bench-top system can revolutionize their studies by providing high-resolution, multi-dimensional imaging of live samples. Join us to explore the future of super-resolution microscopy and its applications in unraveling the complexities of cellular biology.
Date: Sunday, December 15
Time: 10:15am – 11:00am
Location: Meeting Room 22
Level: Intermediate
Speaker: Winfried Wiegraebe, Ph.D.; Product Manager Super-Resolution Microscopy
Luxendo Light-Sheet and Acquifer Automated Microscopy: 3D Imaging From High-Resolution to High-Throughput
Abstract: Life happens in a 3-dimensional world. To study this, Bruker offers a suite of fluorescence microscopy tools to enable research of biological processes on scales ranging from individual cells, organoids, tumors, and even entire organisms. In this presentation, we will focus our discussion on two different approaches for 3D imaging: our Luxendo line of light-sheet microscopes and the Acquifer Automated Microscopy platform. The Luxendo Light-Sheet Fluorescence Microscopes allow for long-term 3D imaging of delicate living samples such as spheroids or embryos as well as for large-scale 3D imaging of large, cleared samples (e.g., mouse brains). Specifically, we will highlight our new features for light-sheet creation and sample mounting. In addition to this, we will discuss the Acquifer Automated Microscopy platform, enabling phenotypic screening of the same range of samples with powerful support for smart and interactive imaging assays. Concerned with how to handle the large amounts of data created with these microscopes? Stick around for a discussion of the capabilities of our Acquifer HIVE Data Solution for the safe storage, reliable and fast access, and powerful processing of your imaging, sequencing, and omics data.
Date: Saturday, December 14
Time: 11:15am -12:00pm
Location: Room 22
Level: Intermediate
Speaker: Chris English
Featured Products and Technologies
Meet Us at the Show
Throughout the event, our team will be at the booth showcasing our latest technology and will be available to answer your questions.
Schedule a meeting with us to discuss your unique measurement needs and challenges and find out how Bruker technology can advance your materials research.
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