Nanomechanical Test Instrument

Hysitron BioSoft

In-situ indenter for soft biomaterials mechanical characterization

Hysitron BioSoft

Bruker’s Hysitron BioSoft In-Situ Indenter is a first-of-its-kind instrument specifically designed for multiscale quantitative mechanical testing of biological materials and soft matter, such as hydrogels. BioSoft synchronizes powerful mechanical and optical characterization techniques to achieve a comprehensive understanding of the mechanics of biomaterials. This portable system integrates with existing inverted optical microscopes to bring advanced biomechanical testing capabilities into your laboratory.

Quantitative
mechanical property measurements
Provides a unique combination of force sensitivity and displacement range specifically engineered to measure biological specimens from sub-cellular to tissue levels.
Maximized
test flexibility
Easily integrates with inverted microscopes to characterize a broad range of biological materials.
Advanced
BioMech control module
Performs interchangeable load, displacement and open-loop control within a single test.
Testing Modes

Transform Your Optical Microscope into a Powerful Biomaterials Test System

Quantitative Soft Biomaterials Characterization

Overlay of 55 indentation curves into polyacrylamide gel showing a high degree of repeatability.

The Hysitron BioSoft provides a unique combination of force sensitivity and displacement range to deliver quantitative mechanical property measurements on the sub-cellular to tissue levels. Streamlined system operation delivers the results you need quickly, minimizing the need to become an experimental expert and providing an easy portal to make life changing discoveries.

Quantify the Mechanics of the Biological World

Incorporating decades of knowledge in biomatter nanomechanical testing, Bruker's BioIndenter Series was specifically developed to help you understand the mechanics of soft matter. Its portable compact platform and adaptability enables its users to transport nanomechanical testing capabilities into any laboratory.

Quantitative Testing at Elevated Temperatures

Hysitron BioSoft integrated with the BioSoft PetriDishHeater (left) and indentation curves measured on bio-inks (right). Fit of Hertz Elastic Contact: G1 = 75.2 ± 17kPa; G2 = 53.7 ± 16.1kPa

The BioSoft PetriDishHeater can be integrated with Hysitron BioSoft to conduct quantitative in-situ mechanical testing at room temperature (RT) up to 60°C with 0.1°C precision. This capability allows researchers to confidently investigate biological and soft materials at constant temperatures to more accurately reflect real-world conditions.

Upgrade Options and Add-Ons

Expand Hysitron BioSoft's Capabilities

LEARN MORE:

Contact us for more information about available upgrade options and how Hysitron BioSoft can be configured to meet your specific measurement needs now and grow with your research going forward.

Hysitron BioSoft FAQ

Frequently Asked Questions

What is BioSoft?

BioSoft is a Bruker’s nanoindentation platform specifically designed for soft materials and biological samples, enabling quantitative mechanical property measurements in combination with an optical microscope.

What types of materials can BioSoft measure?

Hydrogels, tissues, polymers, biomaterials, cells, organoids, 3D scaffolds, and other soft/viscoelastic systems

What makes BioSoft different from conventional nanoindenters?
  • Ultralow-load transducer with sub-μN force resolution
  • Specialized fluid-compatible probes
  • Optimized system design to minimize noise and drift in hydrated environments
What mechanical properties can be obtained using BioSoft?

Elastic modulus, viscoelastic response, creep, stress relaxation, adhesion, and time-dependent deformation

Can BioSoft operate in liquid environments?

Yes. Biosoft is designed for in-liquid measurements, making it ideal for hydrated biomaterial testing.

Is BioSoft compatible with imaging?

Yes. Optical or fluorescence microscopy can be integrated to correlate mechanical data with structural changes.

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