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Bioimaging Across Scales

Light-sheet fluorescence microscopy has become the method of choice for non-invasive imaging of a variety of live and cleared biological samples ranging from subcellular structures to cells, tissues and whole embryos, e.g. Drosophila and Zebrafish.

Among other features, the significantly reduced photodamage effects and the very high acquisition speed make light-sheet fluorescence microscopy stand out.

The MuVi SPIM, the InVi SPIM, and the QuVi SPIM systems, as well as the solutions for cleared sample imaging and photomanipulation, have been built up around your sample to meet the requirements of your application. Take a look at the different examples.


  • Embryogenesis & Developmental Biology
    Light-sheet fluorescence microscopy enables the observation of events in real time for several days.
  • Organoids Research
    Organoid research has been established as an essential tool for studies in cancer research, drug discovery and regenerative medicine.
  • Plant Research
    The application of light-sheet fluorescence microscopy for plant research has allowed in vivo studies of plant cell and tissue biology.
  • Cell Culture
    Light-sheet microscopy applied to cell culture imaging reduces negative effects on cell behavior and development.
  • Neurobiology & Neurodevelopment
    Light-sheet fluorescence microscopy has enabled imaging of the central nervous system including large networks of neurons, and even whole cleared brains (e.g. mouse).
  • Cleared-Sample Imaging
    Clearing tissue techniques modify the optical properties of usually opaque samples to render them transparent while keeping their structure intact.
  • Other
    Many other applications can benefit from the advantages of imaging with light-sheet microscopy, e.g. marine biology.


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