Mass Spec Webinars

On-Demand Webinar Streaming

Bruker Webinars - tune in and get the latest insights about new technologies, scientific developments, innovative analytical methods and catch late-breaking news.

You weren't able to attend one of our live webinars or you would like to watch it again? Here you can stream all of our webinars on-demand at your convenience. Just click on the respective links and register.

Recent Webinars

Label-free techniques for Drug Discovery:
Surface Plasmon Resonance (SPR) and MALDI Mass Spectrometry for Primary (HTS) and Secondary Screening

Seminar overview

The webinar will update on latest developments in MALDI mass spectrometry for high-throughput screening and CPD profiling (rapifleX MALDI PharmaPulse) and introduce Bruker's new surface plasmon resonance (SPR) instrument, the SIERRA SPR-32. Beside technical details explaining the latest developments, synergies between MALDI mass spectrometry and SPR will be discussed.

Key Topics

  • Primary and Secondary Screening in Drug Discovery
  • Label-free technologies to reduce artefacts / importance of controls in SPR experiments
  • Kinetic characterization: Determination of KDon- and KDoff-rates of compounds (SPR)
  • Automation strategies to maximize throughput (SPR and MALDI)


Meike Hamester

Dr. Meike Hamester

Director Small Molecule Pharma Business

Dr. Meike Hamester studied chemistry at the University of Hamburg, Germany. She worked 18 years in the field of mass spectrometry at Thermo Fisher Scientific. Since 2012 Meike works for BRUKER Daltonik in Bremen.

Sven Malik

Dipl.-Ing. Sven Malik

Senior Application Specialist

Dipl. -Ing. Sven Malik studied Bioprocess-Engineering at TU Dresden. He worked 8 years in the field of surface plasmon resonance. Since 2012 Sven worked for Sierra Sensors GmbH (now Bruker). 

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TimstofPro 180px

timsTOF Pro and PASEF: Multiplying Sequencing Speed and Sensitivity in Proteomics

Speakers: Andreas-David Brunner, Mass Spectrometry Instrumentation,Max Planck Institute of Biochemistry; Florian Meier, Mass Spectrometry Instrumentation, Max Planck Institute of Biochemistry; Prof. Juergen Cox, Ph. D., Computational Systems, Max Planck Institute of Biochemistry

Applications of proteomics to cell biology and biomedical research require further developments of mass spectrometry (MS) technology to overcome long-standing limitations in speed, sensitivity and robustness. Trapped ion mobility spectrometry (TIMS) coupled to a quadrupole time-of-flight (QTOF) analyzer has shown much promise in this regard. Here, we further show the integration of ‘Parallel Accumulation followed by Serial Fragmentation’ (PASEF, Meier et al., J Proteome Res 2015).

In this Webinar, we will explain the fundamentals of this technology and give examples of how the timsTOF Pro was applied for high sensitivity and high speed label-free proteome quantification. We will furthermore discuss factors for the success of these experiments, starting from sample preparation and liquid chromatography to method development and data analysis with MaxQuant.

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Scientists' Choice Awards Winner

Label-Free High-Throughput MALDI TOF Mass Spectrometry in Drug Discovery

Speaker: Matthias Trost, Professor of Proteomics, Newcastle University

The presentation will give a current overview of label-free high-throughput MALDI TOF mass spectrometry and its use in drug discovery screening. It will explain the basics of MALDI TOF mass spectrometry and the benefits of label-free screening compared to current labeled approaches. Data presented will focus on enzymes in the ubiquitin system (deubiquitylases, E2/E3 ligases) and protein kinases.

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TargetScreener HR

Eliminating False Positives and Negatives: Correctly Report Results the First Time

Speaker: Dr. Carsten Baesmann, Director of Applied Markets Solutions Development, Bruker Daltonics

The webinar provides a detailed overview of how high-resolution mass spectrometry and data acquisition using a 'catch all compound' acquisition scan mode can reduce instances of reporting false positives and negatives.

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Recent Webinars


SCiLS Lab: Feature Extraction with Principal Components

Mass spectrometry imaging produces highly complex data that is difficult to access and understand. This webinar demonstrates feature extraction with principal components and advanced visualization techniques in SCiLS Lab

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Webinar Toxicology

Toxtyper Screening - A New Kind of Forensic Evidence

Speaker: Dr. Andrea Steuer, Forensic Toxicologist Dept. of Forensic Pharmacology & Toxicology, Institute of Forensic Medicine, Zürich

The webinar briefly introduces the field of forensic toxicology and focus on the use of the Toxtyper system for urine screening within this field.

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Webinar Archive

Date Title
Webinar series uHTS Mass Spectrometry in Drug Discovery
24.05.2017 Webinar series part 1: Changes and Challenges in Early Drug Discovery Today

Presenter: W. Adam Hill, CEO, Prospective Research Inc., Beverly, MA

Success or failure in drug development goes back to the early stages of drug discovery. In a series of webinars conducted together with the Division of Pharmacy Professional Development at the University of Wisconsin, we would like to discuss with you todays challenges, oppurtunities and state-of-the art technologies in early drug discovery. In the first installment of the series, W. Adam Hill will give an insight into the challenges and limitations researchers are facing in early drug discovery.
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31.05.2017 Webinar series part 2: High-throughput MALDI TOF Mass Spectrometry for Drug Discovery in the Ubiquitin System

Presenter: Matthias Trost, Professor at The Institute for Cell and Molecular Bioscience (ICaMB) of Newcastle University, UK

In this webinar Matthias Trost shows how the drug discovery process can be accelerated beyond conventional technologies with advanced mass spectrometry technology.

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07.06.2017 Webinar series part 3: Advancements in MALDI-TOF Mass Spectrometry towards Ultra High Throughput Screening

Presenter: Melanie Leveridge, Head Screening Profiling and Mechanistic Biology, GlaxoSmithKline, Stevenage, UK

In this webinar of the Bruker-DPPD webinar series, Melanie Leveridge will discuss how the MALDI-TOF works in a real life pharmaceutical application. Real pharma examples and application vignettes are presented by a pharmaceutical Company Researcher (e.g. GSK) using automated MALDI-TOF to push back the boundaries and limits of conventional methods. This should be the message which validates the arguments and assertions made earlier.

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Date Title
27.07. 2017

The Toxtyper Screening Solution in the Forensic Lab
Presenter: Jürgen Kempf Institute of Forensic Medicine, Medical Center – University of Freiburg
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20.06. 2017

Can metabolomics research help to discover developmental disorders in children related to environmental contaminants?
Presenter: Pim Leonards, Professor, Environmental Bioanalytical Chemistry Environment & Health, VU University of Amsterdam, Netherlands
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07.06. 2017

Proteoforms: a matter of preservation in proteomics
Presenter: Dr.Hans Wessels, Proteomics Scientist, Radboud University, Nijmegen, Department of Laboratory Medicine
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20.12. 2016

Enabling Isotopic Fine Structure Mass Spectrometry
Presenters: Christopher Thompson, Ph.D., Senior Applications Developer, Bruker Daltonics; Raymond March, Ph.D., Professor Emeritus of Chemistry, Trent University
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15.12. 2016

Label-free ultra-high-throughput screening by MALDI Mass Spectrometry
Presenters: Dr. Meike Hamester, Director Small Molecule Pharma Business, Bruker; Dr. Jens Fuchser, Product Manager MALDI TOF, Bruker
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07.11. 2016

Increasing arginine production in Corynebacterium glutamicum by rational strain design in combination with metabolomics and proteomics
Presenters: Dr. Aiko Barsch, Market Manager Metabolomics, Bruker Daltonics, Bremen
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29.09. 2016

The Routine Application of LC-High Resolution Mass Spectrometry to Detect and Quantify Pesticides Residues in Food
Presenters: Lucie Humbert, SCL, Montpellier, France
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22.09. 2016

Target and non-target metabolomics in environmental research; developmental neurotoxicity of biocides
Speakers: Prof. Pim Leonards, Institute for Environmental Studies, VU University of Amsterdam, Netherlands
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06.09. 2016

Hydrogen Exchange Mass Spectrometry automation for the maXis Ultrahigh Resolution QTOF
Speakers: Prof. Dr. Matthias P. Mayer, Center for Molecular Biology (ZMBH), University of Heidelberg
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26.07. 2016

Applications of GC–MS-MS and LC-Ion Trap MS-MS in Postmortem Forensic Toxicology
Speakers: George Hime, Miami-Dade Medical Examiner Department Toxicology Laboratory; Joe Kahl, Forensic Toxicologist, Miami-Dade Medical Examiner Department Toxicology Laboratory;Elisa Shoff, Forensic Toxicologist, Miami-Dade Medical Examiner Department Toxicology Laboratory
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28.06. 2016

Structure Elucidation with Trapped Ion Mobility Spectrometry
Presenters: Dr. Christian Bleiholder, Ph.D., Assistant Professor of Chemistry & Biochemistry, Florida State University
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28.06. 2016

Streamlining Drug Development Native LC-MS for Rapid Screening and Drug Product QC Release Testing of ADCs
Speakers: Dr. Lieza Danan-Leon, Senior Scientist, Head of Mass Spectrometry, Stemcentrx.
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16.06. 2016

Uncovering Metabolic Pathways in Disease to Support Drug Discovery Using High Resolution MALDI Imaging Mass spectrometry
Speakers: Ellen Jones, Ph.D., MALDI Imaging Research Center, Genentech; Dr. Dennis Trede, Ph.D., Managing Director, SciLS Bremen
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16.06. 2016

Rapid and Sensitive Quantitation of Approximately 100 Synthetic Cannabinoids In Serum by UHPLC-Triple Quadrupole Mass Spectrometry
Speakers: Rafaela Martin, PhD, Applications Specialist, Bruker Daltonics
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24.05. 2016

High-throughput MALDI TOF mass spectrometry for drug discovery
Speakers: Dr Matthias Trost, MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee
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17.05. 2016

Biosynthetic Function of Genes in Plants and Their Consequences in Insects – a Metabolite Profiling Approach Driven by Automatic Compound Identification
Speakers: Sven Heiling, Ph. D., Department of Molecular Ecology, Max Planck Institute for Chemical Ecology
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13.04. 2016

Top, Down…Bottom, up… Middle what? What Does it All Mean? And Why is it Important for mAb Characterization?
Speakers: Jason S. Wood, PhD, Bruker Daltonics
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07.04. 2016

A comprehensive workflow for glycopeptide analysis
Speakers: Kristina Marx and Stuart Pengelley, Bruker Daltonics
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23.03. 2016

Meeting the challenges of metabolite identification in MS-based metabolomics
Speaker: Prof Dr Liang Li, University of Alberta
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04.11. 2015

New Developments in Quadrupole Time-of-Flight Instrumentation for Quantitative Proteomics
Speaker: Scarlet Beck, Florian Meier
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09.09. 2015

Advances in Glycopeptide Analysis
Speaker: Kathrin Stavenhagen, M.Sc.
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12.08. 2015

Development of Spectral Libraries, Predictive Software, and UHPLC-MS-SPE-NMR Technologies for Large-Scale Plant Metabolite Identification
Speaker: Lloyd W. Sumner, Ph.D.
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09.07. 2015

Application of High Resolution LC-QTOF Mass Spectrometry for Target and Non-Target screening of Emerging Environmental Contaminants in Surface and Waste Waters
Speaker: Nikolaos S. Thomaidis, Assoc. Prof.
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08.07. 2015

MALDI Imaging Moving Into The Fast Lane: Toward High Throughput Tissue Typing
Speaker: Dr. Ron M.A. Heeren
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Automated De Novo Identification and Profiling of Disulfide Bonds in Biotherapeutics Including Analysis of Disulfide Bond Scrambling in Monoclonal Antibodies
Speaker: Jason S. Wood, Ph.D.
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Accelerating Pharma R&D using Mass Spectrometry and NMR
Speaker: Dr. Meike Hamester, Dr. Matthias Trost, Dr. Jens Fuchser
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06.02. 2014

Identification of Microorganisms using MALDI-TOF
Speaker: Jennifer Reyes
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