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Very Fast Reaction Monitoring and Optimization

InsightXpress enables the monitoring of fast reactions and rapid, screening of reaction conditions.

InsightXpress is the fastest of the Insight product line and ideal for rapid reaction optimization and reaction monitoring of fast reactions MR.  

InsightXpress’s new stop-flow delivery pumps enable the screening of reaction conditions by NMR at an unprecedented speed. Using InsightXpress, Professor Lloyd-Jones and his colleagues at the University of Edinburgh gathered insights into the mechanism and kinetics of the Suzuki-Miyaura protodeboronation side reaction. They were able to monitor the decay of a reagent with half-life time of 1 second.

Key Features

  • Used when needed (Compatible with Open Access System)
  • „„Rapid and easy set-up
  • „„Low sample volumes (<600 μL/shot)
  • Unlimited shots
  • Variable ratios of reagents to explore different reaction conditions
  • Accurate temperature control (detailed kinetics studies)
  • Pre-magnetization of reagents for quantitative information
  • „„Precise timing using a trigger pulse
InsightXpress
  • Reproducible with stable measured volume
  • „„Dead-time less than 150 ms, enabling the monitoring of fast reactions
  • „„Fast flow-rate injection (0.2 – 2 ml/s)
  • In-situ cleaning using dedicated solvent flush line
  • Compatible with all Bruker 5 mm Probes
  • Easy automatic optimization of NMR parameters
  • Intuitive software for data acquisition and analysis

NMR System requirements

  • Windows 10, 7 or Linux running TopSpin 3.5 and above
  • AVANCE III console and newer
  • 5 mm RT- or Cryo-probe
  • Shielded Bruker Magnet

InsightMR Software

InsightMR software is a platform designed for the analysis of chemical processes by NMR. Integrated acquisition control and data processing features enable on-the-fly acquisition parameter adjustment based on real-time kinetic data.

  • A single interface for automated acquisition control and interactive data analysis.
  • On-the-fly acquisition parameters adjustment based on real-time kinetic data.
  • Straightforward experiment set up. Default kinetics parameters provided for both deuterated and non-deuterated solvents.
  • Rapid and effortless handling of hundreds of stacked spectra.
  • Supports acquisition, processing and analysis of series of 1Ds (different nuclei), interleaved experiments and multi samples in parallel.
  • Integrates Dynamics Center, TopSpin and IconNMR into one platform.

InsightXpress Unit

The system sits on top of the NMR system*. The flow-tube, connected to its transfer line is inserted into the magnet until it reaches the probe.

The pumps can be prepared for delivery before the acquisition with a few mouse clicks.

InsightMR™ software is now equipped with reparation experiments to automatically optimize NMR acquisition (e.g. solvent suppression and shimming). The injection of reagents and the start of the NMR acquisition is co-ordinated by a trigger pulse.

Ascend 400

Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory

Download LabScape Brochure