Very high spatial resolution: In-plane (19.5 µm)², slice thickness: 150 µm, while maintaining good contrast and signal-to-noise ratio. Figure 5: Images located approximately at position Bregma -2.7 mm. (a) Full field of view FLASH image, (b) shows an expa
(a,d) Expanded FLASH images, (b,e) phase images of the very same FLASH images, and (c,f) corresponding Nissl stained plates. Images (a-c) Bregma -2.7, (d-f) Bregma -1.9. MRI acquisition details: Resolution in-plane: (19.5 x 19.5) µm², field of view: (1.5
(a,d) Expanded FLASH images, (b,e) phase images of the very same FLASH images, and (c,f) corresponding Nissl stained plates. Images (a-c) Bregma -2.7, (d-f) Bregma -1.9. MRI acquisition details: Resolution in-plane: (19.5 x 19.5) µm², field of view: (1.5
Six full field of view coronal RARE slices of mouse brain in vivo. Acquisition details: RARE, 6 echoes, resolution: (29 x 29 x 200) µm³, TR: 3500 ms, TE: 25.3 ms, scan time: 25 min 40 s. Picture made at 15.2T field strength
Direct comparison of high-resolution in vivo mouse brain images with Nissl stained plates. Resolution in-plane: (29 µm)², Slice thickness: 200 µm. (a) Full field of view coronal RARE image. Picture made at 15.2T field strength
Direct comparison of high-resolution in vivo mouse brain images with Nissl stained plates. Resolution in-plane: (29 µm)², Slice thickness: 200 µm. Image (b) shows an expanded view of the hippocampal area, and image (c) a corresponding Nissl stained plate
3D Time of Flight (ToF) angiography in vivo without contrast agent, (a) MIP rotating around AP axis. Acquisition details: GEFC, TR: 37 ms, TE: 3.3 ms, matrix: 384 × 256 × 256, resolution: (49 µm)³ isotropic. Picture made at 15.2T field strength
3D Time of Flight (ToF) Angiography in vivo without contrast agent, (b) MIP rotating around LR axis. Acquisition details: GEFC, TR: 37 ms, TE: 3.3 ms, matrix: 384 × 256 × 256, resolution: (49 µm)³ isotropic. Picture made at 15.2T field strength
In vivo murine brain micro-imaging with resolutions slowly approaching cellular levels becomes feasible at high magnetic field strengths (15.2 T) using a cryogenic RF coil. This may open up new possibilities for research on microstructural changes in gene
The full cycle of a beating mouse heart in MIP representation. IntraGate self-gated angiography (work-in-progress)
Maximum Intensity Projection of mouse spine with MRI CryoProbe. Visualization of posterior intercostal arteries and veins.
Gray-white matter differentiation in fractional anisotropy map. Clear identification of nerve fibers (yellow arrows) in the color-coded diffusion tensor display.
High resolution T2- weighted TurboRARE mouse spine images. Excellent differentiation of gray and white matter.
Triggered Snapshot Time-of-Flight angiography. Visualization of liver vessels with Maximum Intensity Projection
SWI processed FLASH image of a subcutaneous mouse tumor, and the corresponding RARE reference image.
Direct detection of glucose metabolism in mouse brain. After overnight fasting, a bolus of 130 mg/kg [1-13C] glucose was given within 20 sec, f4.
STEAM localized 1H spectroscopy in mouse frontal brain. Minimal evolution of VTJ-coupled resonances due to short echo time (3 ms); Optimal for investigation of macromolecules.
Subcutaneous tumors in mice; Correlation of susceptibility weighted imaging and T2* maps. SWI indicated tumor vascularization. Precise partitioning of the tumor.
Improved definition of small structures such as vessels and fibers compared to standard T2*-weighted protocols.
AD plaque imaging in a 24 month old mouse in both T2- and T2*-weighted contrast. Exemplary plaques are marked with red arrows.
Courtesy Aline Seuwen, ETH Zurich
3D Flash: 40*40*60 μm, TR=400, TE=7.6, α= 30°, 1h17min. Courtesy Aline Seuwen, ETH Zurich
