Due to their genetic similarity to humans and their development from eggs outside of the mother's body, zebrafish are becoming established as a prominent research model for studies ranging from Alzheimer's disease to diabetes. In early stages development can be monitored well via microscopy, since the zebrafish are translucent. However, in later development stages, they become opaque and alternative investigative methods are necessary. As a non-invasive 3D imaging method, MRI can be used to follow zebrafish development. Researchers have now investigated zebrafish cardiac development using preclinical MRI to examine cardiac function and have combined this with µCT for high resolution images.
Listen to researchers from the Max-Planck Institute for Heart and Lung Research talk about their work optimizing the analysis of adult zebrafish cardiac function using MRI and heart morphology with microCT.