In addition to spectroscopy, the increased spectral dispersion also benefits magnetization transfer techniques such as Chemical Exchange Saturation Transfer (CEST) imaging, leading to a high selectivity . Further advantages of chemical exchange techniques at UHF include the higher saturation which can be achieved  and a reduction of the exchange rate relative to the chemical shift .
A recent paper from Chung et al. demonstrated a significantly increased chemical exchange effect for the amine proton signal in rat brain at 15.2 Tesla compared to 9.4 Tesla. An increase of 65% compared to 9.4 Tesla was reported emphasizing the importance of UHF for chemical exchange applications [7,8].
A prominent CEST application which benefits from UHF is GluCEST, which monitors local metabolic defects in neurodegenerative diseases [6,9]. For example, GluCEST was identified in the past to be a potential in vivo biomarker of Huntington’s disease when applied in a knock-in mouse model using UHF , and has recently been used in a mouse epilepsy model, in which chronically methionine sulfoximine (MSO)-seizure-inducing treated mice showed reduced GluCEST contrast in the hippocampus .
 Metabolic Imaging in Neurodegenerative Disease using CEST MRI | Bruker: www.bruker.com/service/education-training/webinars/pci-webinars
 Chung JJ, Choi W, Jin T, Lee JH, Kim S-G. Chemical-exchange-sensitive MRI of amide, amine and NOE at 9.4 T versus 15.2 T. NMR in Biomedicine. 2017;30:e3740. doi.org/10.1002/nbm.3740
 New insights into brain function with molecular and functional MRI of the rodent brain at ultra-high fields | Bruker:
 Pépin J, Francelle L, Carrillo-de Sauvage M-A, de Longprez L, Gipchtein P, Cambon K, Valette J, Brouillet E, Flament J. In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease. Neuroimage. 2016; 139: 53–64. doi: 10.1016/j.neuroimage.2016.06.023
 Bagga P, Pickup S, Flament J, Detre J, Hariharan H, Reddy R. Mapping astroglial glutamine synthetase activity in vivo in a preclinical model of epilepsy using glutamate-weighted CEST (GluCEST) MRI. ISMRM 2019 3121