Unleash Bandwidth to Go Fast and Explore Real-Time Changes

Use bandwidth to go fast, enhance resolution, or anywhere in between.

224 seconds of biological dynamics captured at 8 seconds per frame at 1024 x 256 pixels.

FastScan bandwidth Time vs roughness graphs v1

Record high-speed nanoscale dynamics: see membrane disruption on live bacteria.

Antimicrobial peptides such as CM15 may help address antibiotic resistance. So just how does it facilitate bacterial cell death?

With FastScan, study this problem directly, real-time, in situ. Track close-packed porin molecules on the live bacterium as a CM15 injection causes the development of ripping, protrusions, porelike lesions, and disruption of ordered structures. See how these can lead to volume loss and eventual cell death.

FastScan Atomic Force Microscope

Record high-speed nanoscale dynamics: study emergent anisotropy in phase transitions.

How does a phase transition start at the nanoscale? How does molecular alignment emerge in transitions to crystalline and liquid crystal states?

High-speed, high-resolution FastScan images taken during melting of pre-stressed PDES reveal a subtle backbone persistence. The resulting memory effect leads to regrowth of liquid crystalline domains in the same orientation upon cooling.

PeakForce Tapping video (29 seconds per frame, 512x256 pixels) by N. Erina, A. Mednick, J.H. Kindt (Bruker). Sample courtesy of V.Papkov & N. Makarova, Nesmeyanov Inst. of Organoelement Compounds, Russ.Acad.Sci.

FastScan Atomic Force Microscope

Migrating C2c12 stem cell imaged at 40 seconds per frame.


FastScan Mouse embryonic stem cells v1

Mouse embryonic stem cells obtained over 12hrs with a 40x phase contrast objective.© The Exploratorium, www.exploratorium.edu

Record high-speed nanoscale dynamics: disentangle the mechanism of cell migration.

How do cells move?

The complex process of cell migration is central in the development and maintenance of multicellular organisms. With speed and resolution, directly track the contributions of the cell membrane and underlying cytoskeleton. See the extensions of lamellipodia and actin filaments, and the flowing of cell membranes under stress.

FastScan Atomic Force Microscope

Dimension FastScan Polymer image v1

PHBV crystalization (2.2 µm images, 100 Hz, 256x256 pixels). Sample Courtesy of Dr. Jamie Hobbs, University of Sheffield.

Challenge conventional wisdom at triple digit speeds.

In polymer crystallization, lamella are supposed to grow at constant rate. But do they?

High-speed AFM studies of PHBV crystallization show lamella spurting forward substantially faster than the macroscopic growth rate, then slowing or stopping. Growth is then controlled by the rate of lamella nucleation on dormant lamella, rather than by the growth rate of individual lamellae.

What other assumptions should be challenged?

FastScan Atomic Force Microscope

Combine speed and stability for big data at the nanoscale.

Which amorphous formulation exhibits the onset of API crystallization; after what time; under what conditions?

With Dimension FastScan, fully automate a multi-sample, multi-site study, and get it done — fast.

FastScan Amorphus drug formulationsv2

12 samples, 60 sites, 60 minutes — including navigation, engaging, capturing, withdrawal. Samples courtesy M. E. Lauer, O. Grassmann, F. Hoffmann-LaRoche, Basel, Switzerland.

FastScan Atomic Force Microscope

FastScan measurments v2

Individual Images: 1um, 512x512 pixels

The fastest AFM speeds — completely independent of sample size.

Characterize an entire wafer within 2 hours, including navigation, engaging, capturing, and withdrawal.

Each of the multiple images provides a quantitative roughness measurement at sub-angstrom resolution.

Increase scan speed on even the high-resolution Icon head with Fast Tapping.

Achieve 4X speed gain for samples with nm roughness with adaptive scan option.

Immediately double the imaging speed with bidirectional scan option.

Fast Tapping on SiO wafer

Fast Tapping on ITO