EPR in Pharma

Pharmaceutical Applications of EPR

Sterilization Prozesses

APIs, excipients, final drug formulations, laboratory equipment, and medical devices, may need to go through a sterilization process. The most commonly used sterilization methods are: gamma or electron beam irradiation, dry heat, and pressured vapor sterilization.

However, all of these sterilization processes can generate free radicals:

  • Free radicals are responsible for the degradation of the irradiated materials
  • Free radicals cause alteration of the physico-chemical properties of the sterilized product
  • Free radicals decrease drug potency by partial decomposition during sterilization
  • Free radicals may be a toxicological hazard

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