Preclinical Hyperpolarized Carbon-13 Magnetic Resonance Imaging in Neurological Disease Models
In this webinar, Dr. Myriam Chaumeil from the University of California, San Francisco, will discuss emerging applications for HP-13C MRI in detection of inflammatory cells, such as macrophages, involved in neuroinflammation in various preclinical models, and the potential for this method to fill current gaps in clinical imaging techniques currently available.
The metabolic reprogramming that occurs when inflammatory cells are activated as part of the immune response can be targeted by HP-13C probes in a manner similar to techniques imaging metabolically active cancer cells. This resemblance prompted Chaumeil and colleagues to evaluate the technique for the detection and monitoring of neuroinflammation in cells (e.g. macrophages) and various diseases models, including multiple sclerosis, traumatic brain injury, and Alzheimer’s disease.
What to expect
Data on models of neurological conditions will be presented, as well as a review of what other researchers in the field have been doing. Bruker’s Preclinical BioSpec 3T operating with a cryogen-free magnet, will be introduced, as will plans to develop new probes and translate the methodology to the clinic in the future.
- The technology’s potential to improve diagnosis and therapeutic response in various non-cancer neurological diseases
- Detecting lesions in multiple sclerosis and potentially differentiating disease subtypes
- Potential to detect trauma early on in traumatic brain injury
- Potential to diagnose Alzheimer’s early in disease course
- Fundamental concepts of HP-13C MR
- Current advantages of using the BioSpec 3T and plans to develop new hyperpolarized probes with long lifetimes
Who should attend?
This webinar would appeal to pre-clinical researchers, people interested in imaging neurological disorders and neuroscientists who are working in industry or academia. It would also appeal to clinicians interested in potential future applications and scientists involved in novel MRI applications.