Biologically relevant small animal models have become important tools for the study of the fundamental aspects of human system function and dysfunction. Understanding has been greatly enhanced by observing changes, at systemic, organ, tissue, cell, and molecular level, in response to different physiological or environmental conditions and disease states, under prescribed experimental conditions.
In vivo assessments eliminate the need to sacrifice the animal, precluding collection of longitudinal data. In vivo imaging modalities, such as magnetic resonance imaging (MRI), have thus greatly enhanced such research.
MRI is a particularly attractive imaging option for the evaluation of animal models since it provides good spatial resolution without the need for harmful radiation. It also has excellent contrast to distinguish between normal and pathological tissue. In addition to providing anatomical information, MRI can perform functional evaluation through for example quantification of flow, tissue diffusion, and perfusion, or visualization of changes in blood oxygenation. Both structural and functional MRI are especially valuable for non-invasive study of the animal.
Bruker's small animal MRI systems for preclinical and molecular magnetic resonance imaging research deliver images of living organisms with high spatial and temporal resolution. The BioSpec series combines state-of-the-art MRI CryoProbe™ sensitivity booster technology with proven translational to ultra- high-field magnet technology.
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