the mininspec formcheck

Benchtop Solution to Quantify Solid Forms

Easy-to-use benchtop system meets the analytical power of NMR to determine the ratio of either different drug components or various solid forms in a substance.

Quantitation of components in solid mixtures like formulated materials is crucial in material sciences. Especially in the pharmaceutical industry, API (Active Pharmaceutical Ingredient) form characterization and quantification play a central role from early drug development to manufacturing, including knowing how the presence of these solid forms is influenced by the production and storage of drugs, as well as interactions with excipients. Current API quantification methods can be expensive, require laborious calibrations or lack accuracy.


Bruker makes use of reliable and affordable TD-NMR (Time-Domain Nuclear Magnetic Resonance) to monitor phase purity and quantify physical API forms including amorphization. The patent pending minispec Form Check uses 1H or 19F relaxometry data as fingerprints for expected components in solid mixtures, superseding excessive calibration, delicate sample preparation and a high level of expert knowledge.


Benefits of the minispec Form Check

  • Accurate phase quantification of the API lead form in the presence of other polymorphs or excipients, incl. amorphous quantification
  • No requirements regarding sample texture or homogeneity (tablets, gels, polymers), drug loading
  • Benchtop system: low footprint & costs
  • Ease-of-use: non-expert workflow from calibration to project report
  • Minimal sample preparation
  • Straightforward & fast calibration
  • Automated patent pending quantification analysis
  • Non-destructive & non-invasive: samples can be re-used for other purposes