In this webinar, DNP applications in the pharmaceutical industry and pharmaceutical science will be a particular focus, although any biologist, chemist, materials scientist or DNP NMR expert from other fields would also be interested in the discussion. In addition, a broad overview of DNP instrumentation will be given and various features of the NMR spectrometer will be described.
Talking at the seminar will be DNP expert Yongchao Su from Merck (Whitehouse Station, USA) and applications scientist Ivan Sergeyev from Bruker BioSpin (MA, USA).
DNP will be discussed as an enhancement technique in the study of natural abundance samples, which is particularly important in the pharmaceutical field. Ivan will discuss the great need to find techniques that will extend one-dimensional NMR to multi-dimensional NMR.
The use of DNP to study large proteins or complexes of proteins will also be touched on. The technique has boosted NMR signal to the point that it is possible to study anything from globular proteins to various membrane proteins so that specific structural questions can be quickly and easily answered. This is particularly the case in NMR crystallography, which is a hot topic. Yongchao is especially interested in conveying the benefits of DNP in terms of “really making something impossible, possible” and “changing the game board.”
A broad overview of Bruker’s solid-state dynamic nuclear polarization-enhanced NMR system will be given, including novel klystron-based DNP systems, utilizing a lower-power microwave source to generate electron polarization. All of this will tie in with a description of the various academic and industrial applications that users of DNP NMR could employ. The research that will be discussed is in the phase of cutting-edge techniques and applications and should be of interest to anyone wanting to hear how DNP could revolutionize their workflow in years to come.