- Improved IR Biotyper™ system for fast, routine and cost-effective strain typing
for hospital infection control and earlier detection of outbreaks
- FDA clearance for Candida auris identification with the MALDI Biotyper® to support
better diagnostics and monitoring in critically ill patients
ATLANTA, Georgia - June 7, 2018: At the American Society for Microbiology (ASM) Microbe 2018 meeting (www.asm.org), Bruker announces improved solutions for microbial strain typing, hospital hygiene and infection control.
C. auris will be added to the MBT CA system’s cleared reference library, which now contains 334 species or species groups, covering 425 clinically relevant bacteria and yeast species. According to the FDA press release, this is “the first test to identify the emerging pathogen Candida auris, which can cause serious infections in hospitalized patients.” The C. auris identification by a FDA-cleared method does not only help individual patients with an important diagnosis, but it enables direct screening and hygiene measures in order to prevent further spreading of the organism.
Dr. Wolfgang Pusch, Executive Vice President for Microbiology & Diagnostics at Bruker Daltonics, commented: “It is a proven strength of the MALDI Biotyper system and identification algorithms that emerging pathogens, such as Candida auris, can easily be added to its reference library. We are very pleased with this early clearance of the C. auris claim by the FDA in order to make this significant improvement available to the US healthcare system relatively quickly.”
About the Bruker MALDI Biotyper (MBT) Platform
The MALDI Biotyper family of systems enables molecular identification of microorganisms like bacteria, yeasts and fungi. Classification and identification of microorganisms is achieved reliably and quickly using proteomic fingerprinting by high-throughput MALDI-TOF mass spectrometry. The MALDI Biotyper uses a molecular approach based on specific proteomic fingerprints. Many published studies have highlighted its greater accuracy and lower cost, as well as typically much faster time-to-result (TTR).
Applications include clinical routine microbial identification, environmental and pharmaceutical analysis, taxonomical research, food and consumer product safety and quality control, as well as marine microbiology. In many laboratories the MALDI Biotyper has replaced classical biochemical testing for bacterial identification due to the accuracy, speed, extensive species coverage, ease of use and cost effectiveness of the system. Traditional biochemical techniques detect different metabolic properties of microorganisms, can take many hours or even days for completion, and they often lack specificity.
The robust MALDI Biotyper requires minimal sample preparation and offers low consumables cost. The products of the MALDI Biotyper family are available in a research-use-only (RUO) version, as the U.S. FDA-cleared MALDI Biotyper CA System, or in an IVD-CE version according to EU directive EC/98/79. The MALDI Biotyper also has medical device registrations in numerous other countries. RUO versions of the MALDI Biotyper allow selected, high-value antimicrobial resistance tests.
About the Bruker IR Biotyper Platform
The IR Biotyper is a benchtop FTIR spectroscopy system for hospital hygiene and infection control applications. It used the absorption of infrared light by biomolecules, as infrared light induces vibrations and rotations of covalent bonds in biomolecules. Using this principle, the IR Biotyper simultaneously analyses various classes of biomolecules, such as peptides, proteins, carbohydrates and lipids. The resulting spectrum is a molecular fingerprint of the cellular content. This allows robust differentiation between microbial isolates. After an identification of the microbial species with the MALDI Biotyper, the IR Biotyper allows for rapid, cost-effective typing of strains.
Applications include the analysis of outbreak scenarios in hospital hygiene and epidemiology, as well as root cause analysis in microbial food contamination. The IR Biotyper offers low consumables cost, and requires minimal sample preparation. Starting from an isolated culture on an agar plate, a cell suspension is prepared and an aliquot is deposited on the sample plate and air dried. The measurement itself takes a few minutes. After microbial cultivation, the IR Biotyper allows for quick onsite analysis in the hygiene monitoring laboratory, which compares very favorably with the cost and turn-around time to send samples for molecular testing. The IR Biotyper is for research-use-only (RUO) in hygiene, infection control and epidemiology.
About Bruker Corporation (NASDAQ: BRKR)
Bruker is enabling scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker’s high-performance scientific instruments and high-value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy and nanoanalysis, and in industrial applications, as well as in cell biology, preclinical imaging, clinical phenomics and proteomics research and clinical microbiology. For more information, please visit: www.bruker.com.
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Executive Vice President for Microbiology & Diagnostics
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