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LabScape

Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory

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Sensitive, Versatile, Flexible, .... Smart

Features a broadband frequency channel enabling fully automated applications on protons and the widest range of X-nuclei

Features

  • Highest X-nuclei sensitivity combined with excellent proton sensitivity
  • Single probe for direct and indirect detection experiments
  • Increases efficiency and throughput in automation
  • Broadband channel tunable from 15N to 19F under full automation with Bruker ATM™
  • 19F applications including 1H decoupling and vice versa

The SmartProbe™ delivers highest sensitivity on both the multinuclear and proton channel. Its design exclusively features a broadband frequency channel enabling fully automated applications on protons and the widest range of X-nuclei.

For maximum flexibility switching nuclei and probe tuning and matching is performed completely automatically using our ATM™ technology. A further key feature which those probes offer is the ability to observe 19F with 1H decoupling and to perform two-dimensional 1H/19F spectroscopy with superior quality. As two separate coils are used for these two nuclei, artifacts common with double tuning of one coil are eliminated.

The high performance Z-gradient has been designed for highest linearity and shortest gradient recovery times. Combined with its excellent line shape this probe facilitates superior single or multiple solvent suppression using presaturation or pulsed field gradients as required for samples from reaction control, biological samples and body fluids.  The SmartProbe™ is the ideal probe for a wide range of applications from routine 1H NMR measurements on small molecules to advanced research applications including inverse experiments requiring excellent solvent suppression.

  • Observe broadband high resolution probe
  • Fitted with an actively shielded single axis Z-gradient
  • For 5 mm sample diameter and 400 - 600 MHz standard-bore magnets
  • Inner NMR coil can be tuned to observe 19F or any nuclei in the range from 31P to 15N
  • Outer NMR coil is tuned for either 1H decoupling or observation
  • Coil designs have been selected so that the probe can be used for inverse experiments as well as direct X nucleus detection
  • 2H lock channel
  • Automatic tuning and matching accessory, ATM, is standard on this probe

Boron NMR

11B-NMR spectra2D COSY

Boron is a common element used in inorganic and organic compounds. The spectra of decaborane show 11B-NMR spectra with and without proton decoupling. The 2D COSY was recorded in just a few minutes.

Structure Verification and Elucidation

Structure Verification and Elucidation
15N detection experiments and structural work

Structure verification and determination require high quality spectra, which are characterized by excellent lineshape for all nuclei and high sensitivity for all experiments. Well balanced rf channels and matched B1 homogeneity of all coils are a prerequisite, if best sensitivity is to be obtained for any type of application. Excellent solvent suppression enables applications in water, like biomolecular experiments and metabonomic studies.

Fluorine NMR

19F, 1H HMBC Experiment
1 mg/ml fluorouracil 19F, 1H HMBC: 2 min
19F, 1H HOESY and HMBC experiment
1 mg/ml fluorouracil 19F, 1H HOESY and 19F, 1H HMBC

Fluorine is an element found in many pharmaceutical compounds. Essential structural parameters are accessible with heteronuclear NOE experiments, like the HOESY experiment. Fluorine is also used as a spy for studies of the metabolism of active agents, and for enzymatic HTS screening.

(Top) 19F, 1H HMBC Experiment of cytostaticum fluorurazil. The correlation shows a spatial neighbourhood to the proton of the heterocycle.

(Bottom) Comparison of the 19F, 1H HOESY and HMBC experiment. While the HOESY spectrum has a correlation to the proton of the heterocycle, the HMBC shows a correlation to the NH protons.