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MALDI-TOF/TOF for every application and every market

Fast and robust tissue imaging

The rapifleX MALDI tissuetyper is the complete solution for MALDI imaging.

  • Fastest acquisition with up to 40 pixel/second
  • Superior image quality
  • Integration of histology
  • Comprehensive software for the interpretation of large tissue-based biomarker studies
Proteins in sagittal rat brain section measured at 30μm pixel size, ~150000 pixel.
Proteins in sagittal rat brain section measured at 30μm pixel size, ~150000 pixel. (click to enlarge)

Identify Biomarkers directly from tissue

Even from complex  matrices, high quality MS/MS spectra can be acquired and identified.


The imageIDtm workflow combines tryptic digest on tissue with imaging and LC-MS for biomarker identification with confidence.

Tryptic peptide directly identified from tissue
Tryptic peptide directly identified from tissue (click to enlarge)

Accelerating Drug Discovery and Screening

The new rapifleX MALDI PharmaPulse is the first mass spectrometer to offer the speed, specificity and robustness required for large primary screens in drug discovery:

  • The integrated automation solution can process 1536 target plates in less than 8 minutes ~ 0.3sec/sample
  • Up to 100 times less solvent than multi-plexed LC/SPE-MS systems
  • No need for SPE cartridges or HPLC columns
  • Label-free detection accelerates and simplifies assay development and avoids interferences from artifacts
  • Extremely low sample volumes required for detection (typically ~1μL) enables single well kinetic readouts which can reduce the total number of assays required
Full 1536 plate reading in less than 8 minutes
Full 1536 plate reading in less than 8 minutes (click to enlarge)

Verification by high sequence coverage

Top-down sequencing spectrum of the c-ring subunit of M. phlei ATP synthase containing a mutation which causes antibiotics resistance with an overall sequence coverage of 99%.

Modification and mutation sites are detected unambiguously.

Top-down sequencing spectrum
Top-down sequencing spectrum (click to enlarge)

Confident Characterization of Biotherapeutics

Automated disulfide bond determination via LC-MALDI analysis (left) followed by manual quantification of trisulfide forms. Quantitation of trisulfide forms in human IgG1 monoclonal antibodies: the 10 bit digitizer allows for quantitation with high dynamic range down to the relevant 0.1-1% range.

Automated disulfide bond determination via LC-MALDI analysis
(click to enlarge)
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