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scimaX MRMS - Taking science to the max

scimaX enables identification with confidence

Routine sub-ppm mass accuracy and Isotopic Fine Structure (IFS) capability enable high-confidence molecular formulas assignments for known and unknown Targets.

Powered by MRMS Technology, scimaX

  • provides superior eXtreme Resolution and mass accuracy
  • enables routine Isotopic Fine Structure (IFS) analysis for a broad mass range 
  • results in unmatched confidence for compound identification

 

 

IFS
Broad band Isotopic Fine Structure (click to enlarge)

scimaX is easy to site and maintain

scimaX features an integrated MRMS detector equipped with the latest 7T conduction cooled magnet technology. With this, the scimaX footprint is significantly reduced and it fits in a standard lab. Neither filling liquid helium nor a quench line is any more required for these magnets.

scimaX is an integrated and versatile instrument

ESI and  MALDI sources are included as well as several ion activation techniques (CID, (n)ETD, (n)ECD). The ESI source interface is compatible to various optional API sources (APPI, APCI, GC-APCI).

scimaX key features
scimaX key features

scimaX brings “high hanging fruit” within reach…

… for various applications like MALDI Imaging, Metabolomics, Petroleomics, and more. Dramatically improve your productivity by operating round-the-clock by doing your ESI experiments during the day and acquiring MALDI imaging data when you go home. Take on projects that demand exceptional scientific insight and breakthrough with the scimaX.

Learn more about Technical Details

scimaX - the latest MRMS technology for improved productivity

Continuing Bruker’s tradition to forge productivity from technological innovation, scimaX includes several innovative core technologies, to give you performance rivaling high field MRMS at your fingertips.

scimaX ion optics
scimaX ion optics

Patented ParaCell 2xR detector

scimaX comes standard with ParaCell 2xR and AMP detection technology.
The Paracell is a departure from traditional MRMS cell strategies and provides uncommon broadband ion stability resulting in resolution orders of magnitude above other detection schemes. The ParaCell in combination with Absorption Mode Processing algorithms is the prerequisite for routine access to Isotopic Fine Structure (IFS) Information.
Brukers 2xR MRMS instruments use magnetron control technology and the latest high sensitivity, low noise MRMS preamplifier, realizing scientists' long standing vision to exploit harmonics detection schemes and thus increase the experimental speed and instrument productivity without sacrificing resolving power.

7T conduction cooled magnet technology

Bruker‘s revolutionary 7T superconducting magnet technology is the basis of the smaller footprint scimaX MRMS system. This key innovation uses 'conduction cooling' technology, which removes the requirements to fill liquid cryogens or provide quench ducts.

The scimaX can be operated in a standard laboratory space, enabling a wider range of scientific disciplines to gain access to the power of MRMS technology.

Unique ESI/MALDI dual source

Only Bruker MRMS instruments allow operation of a unique ESI/MALDI dual source. This source is included with any scimaX and can either run liquid samples introduced via the Electrospray ionization (ESI) source or from MALDI samples. This highly sensitive MALDI source uses  Bruker's SmartBeam-II™ laser technology and provides several small focus diameters for various applications with different sample preparation techniques. Fast switchover between MALDI and ESI operation is controlled by a software pushbutton, so even simultaneous ESI/MALDI operation is possible.

dual source scimaX
scimaX includes Bruker‘s ESI/MALDI dual source.

Ion activation techniques

scimaX includes a variety of ion activation techniques, including ECD, ETD, CID, EDD, SORI-CID, MALDI-ISD, and NETD capabilities.

Learn more about Applications

scimaX brings “high hanging fruit” within reach …

… for applications like MALDI Imaging, Metabolomics, Petroleomics, and more

MALDI and MALDI imaging

Maldi imaging

scimaX is the ultimate MALDI imaging system for analyzing small to medium sized molecules. Its unrivaled eXtreme Resolution capability and sub- ppm mass accuracy, over a wide mass range, can differentiate images that are only mDa apart and are prerequisite for IFS analysis and formula confirmation.

Analyze complex mixtures directly with the speed and robustness of MALDI.  Visualize and map molecular distributions without molecular labels using MALDI imaging, and determine molecular changes occurring in spatially significant regions of samples.

MALDI Imaging

Phenotyping workflow for large cohorts

AXelerate 100

scimaX eXtreme Resolution allows for chromatography-free acquisition complementary to established NMR based solutions. The MRMS aXelerate workflow breaks free of LC throughput limitations and allows analysis of over 200 samples a day. This solution with MetaboScape based processing enables automatic annotation of molecular formulae for hundreds of known metabolites and molecular formulae generation for thousands of unknown analytes in complex samples for metabolomics and phenomics studies.

Phenotyping

Molecular Classification of Petroleum

Petroelomics

When seeing every molecule matters, MRMS is mandatory to unravel the potentially hundreds of isobaric species in complex mixture analysis, placing MRMS as the industrial standard for Petroleomics.  Now, scimaX enables high field performance at 7T, breaking conventional norms for complex mixture analysis.

Petroleomics

For Research Use Only. Not for Use in Clinical Diagnostic Procedures.