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TargetScreener HR – exceeding MRL's in food analysis and water analysis

Automated workflows to exceed MRL limits

Analyzing for food contaminants to levels which meet regulatory MRL’s in a wide variety of complex matrices is a challenge which TargetScreener HR excels at.  Food analysis and water analysis often present similar challenges in that compound classes such as pesticides and hormones are frequently encountered. The power within TargetScreener HR handles such challenges with ease.

Pesticide analysis and food contaminants screening

Using pesticides to reduce crop damage and to increase horticultural productivity has been implemented on a global scale for many years and, due to their toxicity, the potential migration of these chemicals into the human food and water supply chains presents considerable health concerns. Therefore, the maximum residue level (MRL) permitted for pesticides in food; feeds and water are strictly controlled by local and international regulatory bodies.

TargetScreener HR is specifically designed to deal with these challenges by ensuring that during data acquisition, all compounds eluting from the UPLC column have molecular ion data and fragmentation spectra acquired all of the time. Hence no compound is missed. This is achieved by rapidly cycling between different scan modes to ensure a seamless collection of precursor and fragment ion data in a single dataset.

Such a dataset contains pseudo molecular ions, adduct ions, fragment ions and isotopic pattern together with their retention time. All this information is used by the database to provide enhanced levels of compound identification and hence dramatically minimize the potential for false positive of false negative results.  Measurement of the precursor accurate mass and retention time alone can lead to a high number of false positive results, particularly with complex matrices such as QuEChERS extractions.

Reduce false positive detections.
Illustrating the accumulation of retention time and qualifier ion information to reduce false positive detections.

All detected compounds can then be quantified against their maximum residue levels (MRL) and reports generated with a high level of confidence.

Using TargetScreener HR allows over 2000 compounds to be accurately screened and quantified in water and food analysis ensuring the presence of contaminants are accurately reported.