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Features for protein sample

  • State-of-the-art pulse program library up to 4D experiments
  • Problem-oriented experiment proposals addressing protein backbone assignment and distance measurements 
  • “1-click-optimization” – select the multidimensional experiment of interest and TopSolids automatically detects missing parameters to initialize their optimization
  • Possibility to optimize parameters on standard samples first to save time (e.g. 13C, 15N-labeled glycine, fMLF, GB1, etc.)
  • Automated optional optimizations of spectral widths, carrier frequencies and decoupling parameters
  • Automated processing up to 3D, including phase corrections

Features for material sample

  • Suited for any X nucleus the hardware can measure, including quadrupolar nuclei 
  • Automated optimizations of:

    • High power and low power X pulses
    • HX cross polarization (CP) transfer
    • Parameters needed for 1D and 2D MQMAS experiments

  • Automated basic processing of 2D MQMAS data, including phasing and shearing

    Screenshots and Figures

    TopSolids User Interface

    TopSolids User Interface

    Creating a project and preparing hardware settings using the new TopSolids user interface.

    Set Magic Angle Position

    Set Magic Angle Position

    To guarantee best hardware performance, TopSolids evaluates the quality of the probe setup using automated procedures.

    One Click Optimization

    One Click Optimization

    The “1-Click-Optimization” is a simplification dedicated especially to the unexperienced user, who can select the multidimensional experiment of choice from the problem-oriented proposals without taking care about any parameter needed, since TopSolids automatically starts the optimization of missing values before running the experiment.

    Optional Optimizations

    Optional Optimizations

    New automated optional optimizations of spectral widths and offsets (left) can dramatically shorten the measurement time of multidimensional experiments and well-set decoupling parameters (right) lead to highly resolved spectra.

    MQMAS Experiments Using TopSolids

    Gain insights into material samples with MQMAS experiments using TopSolids. Once the desired X nucleus of choice has been selected, TopSolids guides step by step through the relevant parameter optimizations and setup of the 2D experiment. Automated basic processing of the data results in an already sheared and correclty phased 2D spectrum.

    MQMAS Experiments Using TopSolids

    Parameter Overview

    Keep track about all parameters with the provided TopSolids PDF report at any time.

    Top Solids Parameter Overview