Literature

Papers

Title: In Vivo Imaging of Tumor Physiological, Metabolic, and Redox Changes in Response to the Anti-Angiogenic Agent Sunitinib: Longitudinal Assessment to Identify Transient Vascular Renormalization

Authors:  Shingo Matsumoto 1, Keita Saito 2, Yoichi Takakusagi 1, Masayuki Matsuo 1, Jeeva P. Munasinghe 1, Herman D. Morris 2, Martin J. Lizak 2, Hellmut Merkle 3, Keiji Yasukawa 4, Nallathamby Devasahayam 1, Sankaran Suburamanian 1, James B. Mitchell 1, Murali C. Krishna 1

Location:

1. Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

2. Mouse Imaging Facility, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland.

3. Laboratory for Functional and Molecular Imaging, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland.

4. Department of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

Abstract: The tumor microenvironment is characterized by a highly reducing redox status, a low pH, and hypoxia. Anti-angiogenic therapies for solid tumors frequently function in two steps: the transient normalization of structurally and functionally aberrant tumor blood vessels with increased blood perfusion, followed by the pruning of tumor blood vessels and the ...

Journal: ANTIOXIDANTS & REDOX SIGNALING - March 2014

 


 

Title: Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats
Authors:  Shie-Chau Liu 1, Reem Alomran 1, Sophia B. Chernikov 1, Fred Larte 1, Jason Stafford 1Taichang Jan 1,  Milton Merchant 1, Dirk Zboralski 1, Stefan Zoller 1, Anna Kruschinski 1, Sven Klussmann 1, Lawrence Recht 1, J. Martin Brown 1

Location:

1. Department of Radiation Oncology, Stanford University, Stanford, CA (S-C.L., R.A., S.B.C., F.L., J.S., J.M.B

2. Department of Neurology, Stanford University, Stanford, CA (T.J., M.M., L.R.,); NOXXON Pharma AG, Berlin, Germany (D.Z., S.Z., A.K., S.K.)

Abstract: Tumor irradiation blocks local angiogenesis, forcing any recurrent tumor to form new vessels from circulating cells. We have previously demonstrated that the post-irradiation recurrence of human glioblastomas in the brains of nude mice can be delayed or pre- vented by inhibiting circulating blood vessel – forming cells by blocking the interaction of CXCR4...

Journal: Neuro-Oncology

Papers Abstracts

Title: MRI CEST at 1T With Large meff Ln31 Complexes T m31-HPDO3A: An Efficient MRI pH Reporter
Authors: Giaime Rancan 2, Daniela Delli Castelli1 and Silvio Aime1
Location:

1. University of Turin, Molecular Imaging Center, Torino, Italy.

2. Technical University Munich, Klinikum rechts der Isar, Munchen, Germany.

Abstract: Chemical exchange saturation transfer (CEST) sensi- tivity relies on the prototropic exchange rate kex between the agent and the “bulk” water protons. To exploit large kex, a large frequency separation (Dv) between the pools of exchanging protons is necessary. For this reason, high mag- netic fields are preferred. Herein it is shown that the use of...

Journal: Magnetic Resonance in Medicine - 29 November 2014

 


 

Title: Nanoparticle-Enabled, Image-Guided Treatment Planning of Target Specific RNAi Therapeutics in an Orthotopic Prostate Cancer Model
Authors: Qiaoya Lin 1,2,5, C.S. Jin 1,3, Lili Ding 1, Juan Chen 1, Cheng S. 1 , Huang Huang 4, Zhihong Zhang 5, Gang Zheng 1,2,3
Location:

1. Princess Margaret Cancer Center and Techna Institute - UHN, TMDT 5–362, 101 College Street - Toronto, ON, Canada.

2. Department of Medical Biophysics, University of Toronto, Toronto, On , Canada.

3. Department of Pharmaceutical Sciences, University of Toronto, Toronto, On , Canada.

4. DLVR Therapeutics Inc.- Toronto, ON, Canada.

5. Britton Chance Center for Biomedical Photonics - Wuhan National Laboratory for Optoelectronics-Huazhong University of Science & Technology - Wuhan 430074 , China.

Abstract: The abilities to deliver siRNA to its intended action site and assess the delivery efficiency are challenges for current RNAi therapy, where effective siRNA delivery will join force with patient genetic profiling to achieve optimal treatment outcome. Imaging could become a critical enabler to maximize RNAi efficacy in the context of tracking siRNA delivery....

Journal: Small - 2014

 


 

Title: Feasibility of Sequential PET/MRI Using a State- of-the-Art Small Animal PET and a 1 T Benchtop MRI
Authors: Andreas Schmid 1, Jennifer Schmitz 1 , Julia G. Mannheim 1, Florian C. Maier 1, Kerstin Fuchs 1, Hans F. Wehrl 1, Bernd J. Pichler 1
Location:

1. Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, Department of Preclinical Imaging and Radiopharmac, Eberhard Karls University Tübingen, Röntgenweg 13, 72076 Tübingen, Germany

Abstract: Combined PET/MRI studies receive increasing attention, as their combination allows deeper insight into disease progression. We evaluated a novel 1 T benchtop MRI scanner (1T- MRI) for its use in sequential PET/MRI studies. Procedures: Phantom studies were performed, addressing the attenuation caused by the MRI coils. For in vivo studies, PET/MRI data....

Journal: Molecular Imaging and Biology - 2012

Conference Talk Abstracts

Title: MRI detectable micelles targeting VCAM-1 receptors for imaging inflamed endothelium
Authors: Amerigo Pagoto 1, Rachele Stefania 2 , Francesca Garello 2, Francesca Arena 2Giuseppe Digilio 3,Silvio Aime 2, Enzo Terreno 2

Location:

1. University of Torino, Torino, Italy.

2. University of Torino, Italy

3. University of Eastern Piedmont, Italy

Abstract: The aim of this work is to design new nanosized paramagnetic MRI agent for targeting intravascular epitopes acting as biomarkers of inflammation. Vascular Cell Adhesion Molecules (VCAM-1) are exposed on the activated endothelium with the aim of recruiting and promote the tissue infiltration of cells of the immune system. An intravascular target may overcome the poor sensitivity in the MRI detection of contrast agents and, in addition, the use of soft lipid-based nanoparticles allows for the delivery of a high number of paramagnetic centers at the target site.

Conference: EMIM 2015

 


 

Title: MR-Based Assessment of Small Molecule Diffusion Following Release from Thermosensitive Liposomes
Authors: A.M. Aleong 1,2, J. Zheng 1 , Y. Dou 3, C. Allen 1,3, D. Jaffray 4,5
Location:

1. STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, ON, Canada.

2. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, On , Canada.

3. Faculty of Pharmaceutical Sciences, University of Toronto, Toronto, On , Canada.

4. Guided Therapeutics, techna Institute, University Health Network, Toronto, ON, Canada.

5. Department of Radiation Oncology, University of Toronto, Toronto, On , Canada.

Abstract: Recent advances in drug delivery for cancer therapy have resulted in the development of advanced carriers that release their therapeutic payload at the tumor site following external trigger or endogenous cues....

Conference: WMIC 2014

 


 

Title: Cancer Therapy Response Monitoring Using A Novel MRI Contrast Agent That Self-Assemples In Apoptotic Cells
Authors: A.J. Shuhendler 1, D. Ye 1 , K.D. Brewer 1, M. Bazalova 2, E.E. Graves 2, B.K. Rutt 1, J. Rao 1
Location:

1. Radiology, Stanford University, Stanford,CA, United States.

2. Department of Radiation Oncology, Stanford University, Stanford,CA, United States.

Abstract: Current clinical methods to monitor the therapeutic response of a patient to chemotherapy or radiation therapy are predicted primarly upon measuring tumor size changes over the course of treatment....

Conference: WMIC 2014

 


 

Title: Relaxometry of Bacterially Derived Organelles: A Novel Class of MRI Contrast Agent for Cell Labeling and Tracking
Authors:  Kimberly Brewer 1, Rehan Ali 2, James A Rioux 1, Sui Seng Tee 1, Alexey Bazarov 2, Suleyman Felek 2, Caleb Bell 2Brian K Rut1 2
Location:

1. Radiology, Molecular Imaging Program, Stanford University, Stanford, California, United States.

2. Bell Biosystems Inc, Palo Alto, California, United States

Abstract: Superparamagnetic iron oxide (SPIO) contrast agents have been used for a number of years to label cells for tracking by MRI1-3. However, these particles are significantly disadvantaged in longitudinal imaging because, as cells divide, the amount of iron per cell decreases and eventually the labeled cells can no longer be detected. MR reporter genes exist...

Conference: ISMRM 2014

 


 

Title: In Vivo Monitoring of Caspase-3 Activity with MRI in Response to Different Treatment Modalities
Authors:  Kimberly Brewer 1, Adam J Shuhendler 1, Deju Ye 1, Prachi Pandit 1, Magdalena Bazalova 2, Edward Graves 2, Jianghong Rao 1Brian K Rutt 1
Location:

1. Radiology, Molecular Imaging Program, Stanford University, Stanford, California, United States.

2. Radiation Oncology, Stanford University, Stanford, California, United States.

Abstract: Apoptosis, otherwise known as programmed cell death, is essential for maintaining tissue integrity through the control of cell number and removal of abnormal cell types. Apoptosis is also one of the mechanisms (albeit not the only) through which anti-cancer treatments such as chemotherapy or irradiation induce tumor regression1. One of the key executor...

Conference: ISMRM 2014

Conference Posters

Title: Can we rely on the new 1T “benchtop” systems for investigating cardiac function and viability?
Authors: Daniel James Stuckey 1, Thomas A. Roberts 2 , Laurence H. Jackson 2, Rajiv Ramasawmy 2, Valerie Taylor 2, Anna L David 3, Bernard Siow 2, Mark Francis Lythgoe 2
Location:

1. Centre for Advanced Biomedical Imaging, UCL - University College London, London, London, United Kingdom.

2. Centre for Advanced Biomedical Imaging, UCL - University College London, London, United Kingdom.

3. Institute for Women’s Health, UCL - University College London, London, United Kingdom

Abstract: With the advent of new magnet technology, low strength permanent magnetic field “benchtop” MRI systems claim to make high-performance preclinical MRI accessible to non-specialist researchers by providing an easy to use, cryogen free, compact and cost effective alternative to high field MR systems. Here we assessed the feasibility of using 1T benchtop MRI to measure cardiac function and viability in rats... 

Conference: ISMRM 2015

 


 

Title: Is 1T the new 9.4T? A tool for morphological phenotyping and regional brain volume
Authors: H. Holmes 1, R. Ramasaw 1 , M. Da 1,2, N. Powell 1,2, M. Cardoso 2, M. Modat 2, S Walker-Samuel 1, S Ourselin 2, B. Siow 1, M. F. Lythgoe 1
Location:

1. UCL Centre for Advanced Biomedical Imaging, Division of Medicine and Institute of Child Health, UCL, UK.

2. Centre for Medical Image Computing, UCL, UK.

Abstract: Recently low-field MRI scanners, specificallydesigned for preclinical imaging, have come to market.1 These so-called ‘bench-top’ s canners are com pact, do not require cryogen -cooling, have no s tray field, and m ay s erve as an econom ical alternative to high -field scanners. The question remains as to the best use of these scanners, and whether they can replace the more expensive high-field systems... 

Conference: ISMRM 2015

 


 

Title: Magnetic brain cell stimulation using an MRI contrast agent: superparamagnetic iron oxide nanoparticles (SPIONs)
Authors: Yichao Yu 1, Chris Payne 1 , Vitaliy Kasymov 2, Bernard Siow 1, Quentin Pankhurst 3, AAlexander Gourine 2, Mark F Lythgoe 1
Location:

1. Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom.

2. Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.

3. Institute of Biomedical Engineering, University College London, London, United Kingdom.

Abstract: There is a growing interest in using an MRI system not only for imaging nanoparticles, but also for cellular actuation through them, owing to its ability to manipulate SPIONs in vivo using the magnetic field gradients. Our goal is to develop a new technology that uses magnetic fields to remotely move iron oxide particles and alter cell activity... 

Conference: ISMRM 2015

 


 

Title: Assessment of Experimental Stroke Lesion Size Using 1T Benchtop MRI
Authors: Jed Wingrove 1, Daniel Stcukey 1 , Valerie Taylor 1, Thomas Roberts 1, Rajiv Ramasawmy 1, Bernard Siow 1, Mark Lythgoe 1
Location:

1. Centre for Advanced Biomedical Imaging, Department of Medicine, University College London, London, United Kingdom.

Abstract: High-field MRI (≥ 4.7T) is now routinely used to serially assess stroke lesion size in vivo in rodents using T2-weighted (T2w) and diffusion weighted imaging (DWI) acquisitions at 24 hours post ischemia. However, high field scanners are expensive to purchase and maintain, and require extensive support from MR physicists... 

Conference: ISMRM 2015

 


 

Title: Multimodal Imaging of a Mouse Model of Colorectal Carcinoma Metastasis in the Liver
Authors: Rajiv Ramasawmy 1,2, Sean Peter Johnson 1,2 , Thomas Anthony Roberts 1, Daniel J Stuckey 1, Anna L. David 3, Rosamund Barbara Pedley 2, Mark Francis Lythgoe 1, Bernard Siow 1, Simon Walker-Samuel 1
Location:

1. Centre for Advanced Biomedical Imaging, University College London, London, Greater London, United Kingdom.

2. Cancer Institute, University College London, London, Greater London, United Kingdom.

3. Institute for Women's Health, University College London, London, Greater London, United Kingdom.

Abstract: The recent availability of permanent low-field, “bench-top” MR scanners for small animal imaging offer potential cost-saving over higher field alternatives due to reduced running and infrastructure expenses. The basic imaging offered by these machines allows for non-specialised applications such as the measurement of the growth of orthotopic tumour xenograft models in mice or rats... 

Conference: ISMRM 2015

 


 

Title: Tesla Bench-top MRI of a Mouse Model of Colorectal Carcinoma Metastasis in the Liver: Comparison with 9.4 Tesla
Authors: Rajiv Ramasawmy 1,2, Thomas Roberts 1,3 , Bernard Siow 1, Sean Peter Johnson 1,2, Jack Anthony Wells 1, Alan Bainbridge 4, Rosamund Barbara Pedley 2, Mark Francis Lythgoe 1, Simon Walker-Samuel 1
Location:

1. Centre for Advanced Biomedical Imaging, University College London, London, Greater London, United Kingdom.

2. Cancer Institute, University College London, London, Greater London, United Kingdom.

3. Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London, Greater London, United Kingdom

4. Department of Medical Physics, University College London, London, Greater London, United Kingdom

Abstract: Recently, low-field MR scanners, for pre-clinical imaging, have come to market1. These so-called ‘bench-top’ scanners are compact, do not require cryogen-cooling, have no stray field, and offer a potential cost-saving over higher field alternatives. However, signal-to-noise characteristics are potentially compromised in return for affordability and convenience. One potential area of application for this type of instrumentation is in the measurement of the growth of orthotopic tumour xenograft models in mice or rats... 

Conference: ISMRM 2014

 


 

Title: Implementation of a hardware registration method for fusing micro-PET and micro-MR images
Authors: Traxl Alexander 1, Sauberer Michael 1 , Wanek Thomas 1, Langer Oliver 1,2, Kuntner Claudia 1
Location:

1. Biomedical Systems, Health & Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.

2. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Abstract: Many research institutions perform multi-modality imaging studies with stand-alone scanners for preclinical applications. To interpret such studies, image co-registration tools are used to fuse the images. The usage of a single imaging bed for all modalities offers the possibility to execute sequential magnetic resonance (MR) and positron emission tomography (PET) measurements without the need to reposition the animal. Placing fiducial markers is not always possible due to the restricted space inside the scanners.... 

Conference: EMIM 2014

 


 

Title: Bioinspired Melanin Nanoparticle as a Highly Efficient Nanoplatform for Multimodality Imaging
Authors: S. Hong 1,2, K. Cheng 2 , Z. Cheng 2
Location:

1. Chemistry, Stanford University, Stanford,CA, United States.

2. Radiology / Molecular Imaging Program at Stanford, Stanford University, Stanford,CA, United States.

Abstract: Molecular Imaging that utilizes multimodal imaging probes can provide synergistic advantages over any single modality ....

Conference: WMIC 2014

 


 

Title: Lipid-based nanosystems for the in vivo visualization of inflamed endothelium by MRI
Authors: F. Garello 1, A. Pagoto 1 , S. Rachele 1, F. Arena 1,2, S. Aime 1,2, E. Terreno 1,2
Location:

1. Molecular Biotechnology and Health Sciences, Università degli studi di Torino, Turin, Italy.

2. Center for Preclinical Imaging, Università degli studi di Torino, Colleretto Giacosa (TO), Italy.

Abstract: The term inflammation refers to a generic multicellular process, characterized by changes in the vasculature (increased blood flow and vascular permeability), activation of resident immune competent cells, infiltration of mobile cells of the immune system (neutrophils, macrophages, lymphocytes) and endothelial exposure of several epitopes that primarly aim....

Conference: WMIC 2014

 


 

Title: In vivo antitumor activity of the PI3K inhibitor BKM120 – a MRI controlled therapy study

Authors:  Jennifer Schmitz 1, Heike Niessner 2, Andreas M. Schmid 1, Carsten Calaminus 1, Bernd J. Pichler 1, Friedegund Meier 2
Location:

1. Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany.

2. Department of  Dermatology, Eberhard Karls University Tuebingen, Tuebingen, Germany

Abstract: One of the current challenges in melanoma treatment to date is the high metastatic potential combined with the comparable low severity of symptoms that come along with the primary tumors. Brain metastases occur in 70% of patients with metastatic melanoma and are the leading cause of death in metastatic melanoma patients. Therefore it is of essential ...

Conference: WMIC 2014

 


 

Title: Dendrimersomes: a new vesicular nanoplatform for theranostic application
Authors:  Miriam Filippi 1, Marisa Ferraretto 1, Gilberto Mulas 1, Jonathan Martinelli 3, Lorenzo Tei 3, Mauro Botta 3, Silvio Aime 1,2, Enzo Terreno 1,2
Location:

1. Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

2. Center for Preclinical Imaging, University of Torino, Via Ribes 5, 10010 Colleretto Giacosa (TO), Italy.

3. Dipartimento di Scienze ed Innovazione Tecnologica, Università del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, 15121, Alessandria, Italy.

Abstract: Dendrimers are synthetic molecules with complex branched architectures. Janus Dendrimers are a new class of dendrimers made of two chemically distinct dendritic building blocks resulting in a double-faced compound with one hydrophobic and one hydrophilic moiety...

Conference: ISMRM 2014

 


 

Title: Tesla Benchtop MRI for measuring Lesion Size in an MCAO rat model of Stroke
Authors:  J. Wingrov 1, DJ Stucke 1, V. Taylor 1, TA Roberts 1, R. Ramasawmay 1, MF Lythgoe 1, B. Siow 1
Location:

1. UCL Centre for Advanced Biomedical Imaging, Division of Medicine, London, UK.

Abstract: High field MRI (≥ 4.7 Tesla) [1] is rouQnely used to assess stroke lesion size and penumbra in vivo in rodents using T2, diffusion and perfusion weighted imaging acquisiQons. But, high field scanners are expensive to purchase and maintain. Recently developed, low-field benchtop preclinical MRI systems offer a cost- effecQve alternaQve. Preclinical MRI...

Conference: British Chapter of the ISMRM 2014 

 


 

Title: ParaCEST: imaging pH with high μeff Ln(III) complexes on a 1T permanent magnet.
Authors:  Giaime Rancan11, Daniela Delli Castelli 2, Silvio Aime 2,3
Location:

1. Technische Universität München, München, Bayern, Germany.

2. Universitá di Torino, Torino, Piemonte, Italy.

3. Institute for Advanced Study, Technische Universität München, Garching, Bayern, Germany.

Abstract: Chemical Exchange Saturation Transfer1 (CEST) contrast agents have attracted interest in recent years because of their unique “frequency encoding” properties. So far, the potential of CEST agents has been investigated mainly at high magnetic fields (> 3T). The aim of this work is to seek for CEST agents and procedures for applications at lower field strengths. To generate CEST contrast, the agent has to own mobile proton pools in slow/intermediate exchange, on the NMR time scale, with bulk water (Δω>kex). Paramagnetic molecules (PARACEST) characterized by large Δω values appear the most suitable systems for low field applications. The PARACEST complexes investigated in this work are very stable, neutral chelates of different lanthanide ions... 

Conference: ISMRM 2013

 

 

Application notes

Title: Assessment of the renal elimination of a radiolabelled fluoroquinolone antibiotic using combined PET/MR imaging
Authors: Wanek Thomas 1, Kuntner Claudia 1 and Langer Oliver 1
Location:

1. AIT Austrian Institute of Technology GmbH, Health & Environment Department, Biomedical Systems

Abstract: Fluoroquinolones (FQs) are an important class of antibiotics which possess a broad spectrum of activity against Gram-negative and Gram-positive bacteria. Their antimicrobial activity is based on trapping the bacterial type II topoisomerase enzymes DNA gyrase and topoisomerase IV and thus interfering with DNA unwinding and blockade of the DNA replication ...

 


 

Title: Characterization of Different Drug Treatments Efficacy in morris hepatocellular Carcinoma (HCC) Bearing Rat with a Desktop MRI
Authors:  Luca Venturi 1, Luigi Miragoli 2, Claudia Cabella 2, Lara Caminiti 2, Fabio Tedoldi 2, Silvio Aime 1
Location:

1. Dipartimento di Fisica Sperimentale, Università degli Studi di Torino, Via Giuria 1, 10125, Torino, (TO), Italy.

2. Centro Ricerche Bracco, Bracco Imaging Spa, Via Ribes 5, 10010, Colleretto Giacosa, (TO), Italy

Abstract: New Bruker Icon desktop MRI scanner –Bruker BioSpin MRI- was employed for the therapeutic follow-up of 15 Morris hepatoma bearing rats monitored upon treatment with 2 different regimes. A group of 6 animals was treated with Sorafenib, a multikinase inhibitor blocking tumor cell proliferation and angiogenesis whereas a second group of rats (n=6)...