PET MR

PET/MR 3T simplifies your workflow and supports a broad spectrum of application fields, such as oncology, functional and anatomical neuroimaging, orthopedics, cardiac imaging and stroke models.

Glioma Tumor Development in Mice

PETInsert fig 5
Courtesy: Dr. Uwe Himmelreich, Dr. Matteo Riva, Dr. Willy Gsell, Dr. Cindy Casteels, Molecular Small Animal Imaging Center (MoSAIC), University hospital of Leuven, Belgium

•Early stage mouse glioma (5000 CT-2A cells, 8 days post injection) •Earliest detection of sub-mm³ tumors with superior high-field MRI resolution and soft tissue contrast •Tumor volume extracted from MRI: ~ 0.59 mm3 •Precise definition of the ROI based on high-field MRI allows PET tumor studies at the earliest stage

Tumor Heterogeneity Imaging in Mice

PETInsert fig 4
Courtesy: Sarah Belderbos, Dr. Uwe Himmelreich, Dr. Willy Gsell, Dr. Cindy Casteels, Molecular Small Animal Imaging Center (MoSAIC), University hospital of Leuven, Belgium

•Mouse Xenograft model: Human ovarian tumor cells (SKOV3) were injected subcutaneously in athymic nude mice •Images were taken four weeks after engraftment •T2W-RARE and FDG PET overlays •Both MRI and PET show tumor heterogeneity

Whole body Simultaneous PET/MRI in Mice

PET MRI Sequential Whole body mouse
Courtesy: Dr W Gsell and Prof U Himmelreich, KU Leuven, Belgium

•Large FOV in both modalities allows for simultaneous PET/MR whole body mouse imaging •T1 weighted MRI and PET uptake were dynamically imaged for 65 min Due to the large FOV of 148 mm the biodistribution of different organs can be studied simultaneously

Neurology in Rats

PET MRI Rat Brain CortecesPET MRI Whole Body Rat

18 FDG PET dynamic imaging with focus on neurology. Total body PET imaging: The large static PET FOV enables to simultaneously assess the tracer biodistribution in the whole body enabling kinetic analysis. Top image: the high PET resolution allows for this brain detail showing predominant tracer uptake in brain cortices. Bottom image: kidney function in excreting tracer's metabolites.

18FDG Cardiac Imaging in Rats

PET Rat Dynamic
Courtesy: B Kundu, M Chordia, J Li and S Berr, University of Virginia, US
PET Rat Dynamic TAC
Courtesy: B Kundu, M Chordia, J Li and S Berr, University of Virginia, US

•FDG Dynamic Cardiac Imaging: TAC (Time Activity Curves) •Blood (Inferior Vena Cava) shows peak concentration during injection, diminishing afterwards •Model Tissue (Myocardium) picks up activity progressively, plateauing after 1 hr •In Vivo Dynamic PET Imaging: Blood input function and kinetic parameters of the heart allow to quantify myocardial glucose and fatty-acid metabolism in addition to blood flow (using adequate tracers)

Total Body NaF PET Imaging in Mice

PET mouse NaF
Mouse NaF/PET, 60 minutes. Courtesy: Dr. W. Gsell, Prof. C. Deroose and Prof. U. Himmelreich, KU Leuven, Belgium

•Large FOV allows for Total Body PET imaging •The [F18]-NaF is used typical to detect bone metastasis although it can also be used imaging inflammation. High resolution across the entire FOV: The high resolution can be seen in the spine, rib cage, skull and hind paws.