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Flexible Imaging to Support Evolving Research Needs

The In-Vivo Xtreme II™ provides comprehensive multimodal optical imaging that supports the broadest range of research objectives of any preclinical optical imaging system.

Five imaging modalities are provided, with co-registration of Bioluminescence Imaging (BLI), Multispectral VIS-NIR Fluorescence Imaging (MS-FLI), unique Direct Radioisotopic Imaging (DRI), Cherenkov Imaging (CLI), and X-ray Imaging.

Each modality offers leading individual performance and each has been designed with innovative features to maximize the range of experimental capabilities. This flexibility is particularly critical as research and imaging requirements often shift to unexpected directions as studies progress. The In-Vivo Xtreme II allows researchers to follow these directions without expenses and delays associated with system upgrades or even changing instruments.

Broadest Application Range

BLI continues to be a workhorse application for many optical imaging systems, and is frequently an initial motivator for researchers to adopt optical imaging. Key BLI applications, including sensitive tumor and infection progression monitoring, are supported by an ultra sensitive 4MP CCD (standard).

With fully configured VIS-NIR MS-FLI capabilities (standard), researchers can select the reporter(s) best suited for their application objectives. Further, the multispectral (standard) features support enhanced multiplex capabilities and improved SNR offering potential for more informative study designs.

For imaging radiolabeled small compounds (e.g. drugs), that may be otherwise functionally inactivated with fluorescent labeling, and/or for evaluating candidate nuclear tracers, the unique DRI modality (standard) provides imaging of a broad range of SPECT and PET tracers, including useful non-Cherenkov isotopes, with excellent speed and sensitivity.

In addition to providing excellent anatomical reference for functional modalities, the X-ray system (standard) includes energy calibrations, beam hardening, and geometric magnification that support dedicated studies of skeletal, pulmonary, and adipose tissue. 

Compatible with Most Optical Reporters, Nuclear Tracers, and X-ray Agents

  • Luciferase (all variants), luminol, HRP
  • Fluorescent proteins (all variants)
  • Visible-NIR organic/inorganic fluorophores
  • Cherenkov isotopes (e.g. 18F, 90Y, 177Lu)
  • Non-Cherenkov isotopes (e.g. 99Tc, 111In)
  • Barium sulfate, Visipaque, ExitronTM


Compatible with a range of commercial reagents. Choose the reporter, tracer, agent and substrate to meet your experimental objectives and budget.

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